Increased mitochondrial stress and modulation of mitochondrial respiratory enzyme activities in acetaminophen-induced toxicity in mouse macrophage cells

Agriculture & Biology

• acetaminophen 100%
• macrophages 70%
• toxicity 53%
• enzyme activity 52%
• mice 45%
• apoptosis 36%
• oxidative stress 31%
• cells 24%
• cytotoxicity 22%
• reactive oxygen species 21%
• overdose 17%
• pharmacology 15%
• toxicology 15%
• prostaglandin synthase 14%
• mitochondrial membrane 13%
• dosage 13%
• membrane potential 13%
• cell death 12%
• tissues 11%
• animal models 11%
• glutathione 11%
• electrons 9%
• liver 7%
• metabolism 7%
• enzymes 5%

Chemical Compounds

• Oxidative Stress 78%
• Enzyme Activity 64%
• Reactive Oxygen Metabolite 49%
• Metabolic 42%
• Dose 40%
• Membrane Potential 28%
• Cell Death 28%
• Glutathione 23%
• Pharmacological Metabolism 20%
• Electron Particle 14%

Medicine & Life Sciences

• Acetaminophen 83%
• Macrophages 55%
• Enzymes 43%
• Physiological Stress 17%
• Oxidative Stress 15%
• Apoptosis 13%
• Reactive Oxygen Species 11%
• Mitochondrial Membrane Potential 7%
• Toxicology 6%
• Wounds and Injuries 6%
• Glutathione 6%
• Electrons 5%
• Cause of Death 5%
• Cell Death 5%
• Animal Models 5%
• Pharmacology 4%
• Liver 3%