INCREASED PLASMA PANCREATIC POLYPEPTIDE IN CHRONIC ALCOHOL ABUSE

R. S. FINK, T. E. ADRIAN, D. H. MARGOT, S. R. BLOOM

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Post‐prandial plasma gastrointestinal hormone profiles were measured in nine chronic alcoholics, one and fourteen days after complete alcohol withdrawal. Basal plasma pancreatic polypeptide concentration (PP — mean ± SE mean) was significantly greater in alcoholics (control, 28 ± 5 pmol/l; alcoholics, post‐withdrawal day 1, 62 ± 14 pmol/1, P < 0.05; and post‐withdrawal day 14, 89 ± 17 pmol/l, P < 0.005). The total integrated (TIR) PP response following a test breakfast was similarly elevated (control, 442 ± 63 units; alcoholics, day 1, 1310 ± 231 units, P < 0.005; day 14, 1066 ± 66, P < 0.005). Basal and TIR values for gastrin, gastric inhibitory peptide, insulin and glucagon were similar in alcoholics and controls. As PP has been shown to inhibit pancreatic exocrine enzyme secretion, these findings may help explain the abnormal pancreatic function seen frequently in alcoholics.

Original languageEnglish
Pages (from-to)417-421
Number of pages5
JournalClinical Endocrinology
Volume18
Issue number4
DOIs
Publication statusPublished - Apr 1983
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint

Dive into the research topics of 'INCREASED PLASMA PANCREATIC POLYPEPTIDE IN CHRONIC ALCOHOL ABUSE'. Together they form a unique fingerprint.

Cite this