INCREASED PLASMA PANCREATIC POLYPEPTIDE IN CHRONIC ALCOHOL ABUSE

R. S. FINK; T. E. ADRIAN; D. H. MARGOT; S. R. BLOOM

doi:10.1111/j.1365-2265.1983.tb00587.x

INCREASED PLASMA PANCREATIC POLYPEPTIDE IN CHRONIC ALCOHOL ABUSE

R. S. FINK, T. E. ADRIAN, D. H. MARGOT, S. R. BLOOM

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Post‐prandial plasma gastrointestinal hormone profiles were measured in nine chronic alcoholics, one and fourteen days after complete alcohol withdrawal. Basal plasma pancreatic polypeptide concentration (PP — mean ± SE mean) was significantly greater in alcoholics (control, 28 ± 5 pmol/l; alcoholics, post‐withdrawal day 1, 62 ± 14 pmol/1, P < 0.05; and post‐withdrawal day 14, 89 ± 17 pmol/l, P < 0.005). The total integrated (TIR) PP response following a test breakfast was similarly elevated (control, 442 ± 63 units; alcoholics, day 1, 1310 ± 231 units, P < 0.005; day 14, 1066 ± 66, P < 0.005). Basal and TIR values for gastrin, gastric inhibitory peptide, insulin and glucagon were similar in alcoholics and controls. As PP has been shown to inhibit pancreatic exocrine enzyme secretion, these findings may help explain the abnormal pancreatic function seen frequently in alcoholics.

Original language	English
Pages (from-to)	417-421
Number of pages	5
Journal	Clinical Endocrinology
Volume	18
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2265.1983.tb00587.x
Publication status	Published - Apr 1983
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

Access to Document

10.1111/j.1365-2265.1983.tb00587.x

Cite this

@article{75c62c5e2b2f4e0a9b200a8ada69aff3,

title = "INCREASED PLASMA PANCREATIC POLYPEPTIDE IN CHRONIC ALCOHOL ABUSE",

abstract = "Post‐prandial plasma gastrointestinal hormone profiles were measured in nine chronic alcoholics, one and fourteen days after complete alcohol withdrawal. Basal plasma pancreatic polypeptide concentration (PP — mean ± SE mean) was significantly greater in alcoholics (control, 28 ± 5 pmol/l; alcoholics, post‐withdrawal day 1, 62 ± 14 pmol/1, P < 0.05; and post‐withdrawal day 14, 89 ± 17 pmol/l, P < 0.005). The total integrated (TIR) PP response following a test breakfast was similarly elevated (control, 442 ± 63 units; alcoholics, day 1, 1310 ± 231 units, P < 0.005; day 14, 1066 ± 66, P < 0.005). Basal and TIR values for gastrin, gastric inhibitory peptide, insulin and glucagon were similar in alcoholics and controls. As PP has been shown to inhibit pancreatic exocrine enzyme secretion, these findings may help explain the abnormal pancreatic function seen frequently in alcoholics.",

author = "FINK, {R. S.} and ADRIAN, {T. E.} and MARGOT, {D. H.} and BLOOM, {S. R.}",

year = "1983",

month = apr,

doi = "10.1111/j.1365-2265.1983.tb00587.x",

language = "English",

volume = "18",

pages = "417--421",

journal = "Clinical Endocrinology",

issn = "0300-0664",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - INCREASED PLASMA PANCREATIC POLYPEPTIDE IN CHRONIC ALCOHOL ABUSE

AU - FINK, R. S.

AU - ADRIAN, T. E.

AU - MARGOT, D. H.

AU - BLOOM, S. R.

PY - 1983/4

Y1 - 1983/4

N2 - Post‐prandial plasma gastrointestinal hormone profiles were measured in nine chronic alcoholics, one and fourteen days after complete alcohol withdrawal. Basal plasma pancreatic polypeptide concentration (PP — mean ± SE mean) was significantly greater in alcoholics (control, 28 ± 5 pmol/l; alcoholics, post‐withdrawal day 1, 62 ± 14 pmol/1, P < 0.05; and post‐withdrawal day 14, 89 ± 17 pmol/l, P < 0.005). The total integrated (TIR) PP response following a test breakfast was similarly elevated (control, 442 ± 63 units; alcoholics, day 1, 1310 ± 231 units, P < 0.005; day 14, 1066 ± 66, P < 0.005). Basal and TIR values for gastrin, gastric inhibitory peptide, insulin and glucagon were similar in alcoholics and controls. As PP has been shown to inhibit pancreatic exocrine enzyme secretion, these findings may help explain the abnormal pancreatic function seen frequently in alcoholics.

AB - Post‐prandial plasma gastrointestinal hormone profiles were measured in nine chronic alcoholics, one and fourteen days after complete alcohol withdrawal. Basal plasma pancreatic polypeptide concentration (PP — mean ± SE mean) was significantly greater in alcoholics (control, 28 ± 5 pmol/l; alcoholics, post‐withdrawal day 1, 62 ± 14 pmol/1, P < 0.05; and post‐withdrawal day 14, 89 ± 17 pmol/l, P < 0.005). The total integrated (TIR) PP response following a test breakfast was similarly elevated (control, 442 ± 63 units; alcoholics, day 1, 1310 ± 231 units, P < 0.005; day 14, 1066 ± 66, P < 0.005). Basal and TIR values for gastrin, gastric inhibitory peptide, insulin and glucagon were similar in alcoholics and controls. As PP has been shown to inhibit pancreatic exocrine enzyme secretion, these findings may help explain the abnormal pancreatic function seen frequently in alcoholics.

UR - http://www.scopus.com/inward/record.url?scp=0020701517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020701517&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2265.1983.tb00587.x

DO - 10.1111/j.1365-2265.1983.tb00587.x

M3 - Article

C2 - 6347440

AN - SCOPUS:0020701517

SN - 0300-0664

VL - 18

SP - 417

EP - 421

JO - Clinical Endocrinology

JF - Clinical Endocrinology

IS - 4

ER -

INCREASED PLASMA PANCREATIC POLYPEPTIDE IN CHRONIC ALCOHOL ABUSE

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this