Influence of fibrinogen and C-RP on progression of peripheral arterial disease in type 2 diabetes: A preliminary report

Marijan Bosevski, Golubinka Bosevska, Lily Stojanovska

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Background: Limited studies have suggested that inflammatory biomarkers play a role in the initiation and progression of atherosclerosis in diabetic patients. This study assesses the effect of inflammatory biomarkers: fibrinogen and C-reactive protein (C-RP) on the progression of peripheral arterial disease (PAD) in type 2 diabetic (T2D) patients.Methods: Sixty two patients with T2D and PAD (mean age 60.28 ± 27 years and diabetes duration of 8.58 ± 6.17 years) were enrolled in a cohort prospective study of 36 months. Ankle-brachial index (ABI) was measured in all patients at baseline and after 36 months. Multiple linear regression analysis was used to determine the predictivity of variables for fibrinogen, C-RP, plasma lipid fractions, fasting plasma glucose, Body Mass Index (BMI), duration of diabetes status and the age on changes in ABI value.Results: Linear regression analysis defined F as a predictor for endpoint value of ABI (β = 0.469, p = 0.007). Value of C-RP determinates change of minimal value of ABI (β = 0.449, p = 0.037) and change of mean ABI per year (β = 0.442, p = 0.025).Conclusion: Our data indicate that plasma determination of fibrinogen and C-RP might have a clinical implication in defining the process of progression of PAD in T2D population.

Original languageEnglish
Article number29
JournalCardiovascular diabetology
Volume12
Issue number1
DOIs
Publication statusPublished - Feb 1 2013
Externally publishedYes

Keywords

  • ABI
  • C-RP
  • Fibrinogen
  • Peripheral arterial disease
  • Progression of atherosclerosis
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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