TY - JOUR
T1 - Influence of inclusion complexation with β-cyclodextrin on the photostability of selected imidazoline-derived drugs
AU - Bani-Yaseen, Abdulilah Dawoud
AU - Al-Rawashdeh, Nathir F.
AU - Al-Momani, Idrees
N1 - Funding Information:
Acknowledgement The financial support from the Graduate College of Scientific Research/Jordan University of Science and Technology is gratefully acknowledged. Also, we extend our appreciation to Al-Hekma Pharmaceuticals Co. and Amman Pharmaceutical Industries Co. for generously providing the drugs molecules used in this study.
PY - 2009/2
Y1 - 2009/2
N2 - In this paper, the influence of inclusion complexation with β-cyclodextrin (β-CD) on the photostability of antazoline, xylometazoline, and naphazoline in aqueous media was investigated. The photodegradation reaction of these drugs molecules was explored using UV-vis spectrophotometery-based kinetic analysis and high performance liquid chromatography (HPLC). Quantitative evaluation of the influence of β-CD was judged based on the observed rate constant (kobs), half-life time (t0.5) and t0.1 of the photodegradation reaction and the peak area of the corresponding analyte after photodegradation using HPLC separation. It has been demonstrated that the photostability of these selected imidazoline-based drugs has been enhanced upon forming inclusion complexes with β-CD in aqueous media. Moreover, high consistency regarding the photostability enhancement was obtained using both techniques. Hypothetical structure for 1:1 inclusion complexes was proposed based on molecular mechanics calculations, which in turn provide an insight for the energetically preferential structure of the inclusion complexes. The results obtained demonstrate that β-CD can be utilized as photostabilizer additive for enhancing the photostability of imidazoline-derived drugs molecules.
AB - In this paper, the influence of inclusion complexation with β-cyclodextrin (β-CD) on the photostability of antazoline, xylometazoline, and naphazoline in aqueous media was investigated. The photodegradation reaction of these drugs molecules was explored using UV-vis spectrophotometery-based kinetic analysis and high performance liquid chromatography (HPLC). Quantitative evaluation of the influence of β-CD was judged based on the observed rate constant (kobs), half-life time (t0.5) and t0.1 of the photodegradation reaction and the peak area of the corresponding analyte after photodegradation using HPLC separation. It has been demonstrated that the photostability of these selected imidazoline-based drugs has been enhanced upon forming inclusion complexes with β-CD in aqueous media. Moreover, high consistency regarding the photostability enhancement was obtained using both techniques. Hypothetical structure for 1:1 inclusion complexes was proposed based on molecular mechanics calculations, which in turn provide an insight for the energetically preferential structure of the inclusion complexes. The results obtained demonstrate that β-CD can be utilized as photostabilizer additive for enhancing the photostability of imidazoline-derived drugs molecules.
KW - Imidazoline-derived drugs
KW - Inclusion complexes
KW - Photodegradation
KW - Photostability
KW - β-Cyclodextrin
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U2 - 10.1007/s10847-008-9493-6
DO - 10.1007/s10847-008-9493-6
M3 - Article
AN - SCOPUS:58749099971
SN - 0923-0750
VL - 63
SP - 109
EP - 115
JO - Journal of Inclusion Phenomena and Macrocyclic Chemistry
JF - Journal of Inclusion Phenomena and Macrocyclic Chemistry
IS - 1-2
ER -