Infusion of brain-derived neurotrophic factor into the ventral tegmental area switches the substrates mediating ethanol motivation

Ryan Ting-A-Kee, Hector Vargas-Perez, Mary Rose Bufalino, Amine Bahi, Jean Luc Dreyer, Rachel F. Tyndale, Derek van der Kooy

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Recent work has shown that infusion of brain-derived neurotrophic factor (BDNF) into the ventral tegmental area (VTA) promotes a switch in the mechanisms mediating morphine motivation, from a dopamine-independent to a dopamine-dependent pathway. Here we showed that a single infusion of intra-VTA BDNF also promoted a switch in the mechanisms mediating ethanol motivation, from a dopamine-dependent to a dopamine-independent pathway (exactly opposite to that seen with morphine). We suggest that intra-VTA BDNF, via its actions on TrkB receptors, precipitates a switch similar to that which occurs naturally when mice transit from a drug-naive, non-deprived state to a drug-deprived state. The opposite switching of the mechanisms underlying morphine and ethanol motivation by BDNF in previously non-deprived animals is consistent with their proposed actions on VTA GABAA receptors.

Original languageEnglish
Pages (from-to)996-1003
Number of pages8
JournalEuropean Journal of Neuroscience
Volume37
Issue number6
DOIs
Publication statusPublished - Mar 2013
Externally publishedYes

Keywords

  • Brain-derived neurotrophic factor
  • Dopamine
  • GABA receptor excitation
  • Morphine
  • Mouse
  • TrkB receptor

ASJC Scopus subject areas

  • General Neuroscience

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