Inhibition of pancreatic cancer cell growth

T. E. Adrian

Research output: Contribution to journalShort surveypeer-review

8 Citations (Scopus)

Abstract

Pancreatic cancer cells are resistant to the growth-inhibitory and apoptosis-inducing effects of conventional chemotherapeutic agents. There are multiple genetic and epigenetic events during the process of carcinogenesis that enable the cancer cells to avoid normal growth constraints and apoptosis. Investigation of the mechanisms involved has led to multiple strategies that encourage cell death and apoptosis to occur. The pathways involved are summarized in this review, together with some recently developed strategies to promote cell death in this cancer.

Original languageEnglish
Pages (from-to)2512-2521
Number of pages10
JournalCellular and Molecular Life Sciences
Volume64
Issue number19-20
DOIs
Publication statusPublished - Oct 2007
Externally publishedYes

Keywords

  • Apoptosis
  • Growth inhibition
  • Pancreatic cancer

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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