Inhibition of secretin stimulated pancreatic secretion by pancreatic polypeptide

T. E. Adrian, H. S. Besterman, C. N. Mallinson, G. R. Greenberg, S. R. Bloom

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)


The effect of PP on secretin-stimulated pancreatic secretion was assessed in five healthy subjects. During an intravenous infusion of BPP at a dose which produced plasma levels similar to those seen after meals in healthy young adults the volume and bicarbonate content of duodenal juice was reduced by 25% (P < 0.05) and 24% (P < 0.05) respectively, while protein and bilirubin concentrations were more markedly reduced by 68% (P < 0.0005) and 67% (P < 0.0005) respectively. PP, thus, may be an important inhibitory factor in the control of bilirubin and pancreatic enzyme secretion in man.

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalUnknown Journal
Issue number1
Publication statusPublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology


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