TY - JOUR
T1 - Innate immunity and neuroinflammation
AU - Shastri, Abhishek
AU - Bonifati, Domenico Marco
AU - Kishore, Uday
PY - 2013
Y1 - 2013
N2 - Inflammation of central nervous system (CNS) is usually associated with trauma and infection. Neuroinflammation occurs in close relation to trauma, infection, and neurodegenerative diseases. Low-level neuroinflammation is considered to have beneficial effects whereas chronic neuroinflammation can be harmful. Innate immune system consisting of pattern-recognition receptors, macrophages, and complement system plays a key role in CNS homeostasis following injury and infection. Here, we discuss how innate immune components can also contribute to neuroinflammation and neurodegeneration.
AB - Inflammation of central nervous system (CNS) is usually associated with trauma and infection. Neuroinflammation occurs in close relation to trauma, infection, and neurodegenerative diseases. Low-level neuroinflammation is considered to have beneficial effects whereas chronic neuroinflammation can be harmful. Innate immune system consisting of pattern-recognition receptors, macrophages, and complement system plays a key role in CNS homeostasis following injury and infection. Here, we discuss how innate immune components can also contribute to neuroinflammation and neurodegeneration.
UR - http://www.scopus.com/inward/record.url?scp=84880174102&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880174102&partnerID=8YFLogxK
U2 - 10.1155/2013/342931
DO - 10.1155/2013/342931
M3 - Review article
C2 - 23843682
AN - SCOPUS:84880174102
SN - 0962-9351
VL - 2013
JO - Mediators of Inflammation
JF - Mediators of Inflammation
M1 - 342931
ER -