Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization

A. Adem; S. S. Jossan; R. d'Argy; P. G. Gillberg; A. Nordberg; B. Winblad; V. Sara

doi:10.1016/0006-8993(89)91678-8

Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization

A. Adem, S. S. Jossan, R. d'Argy, P. G. Gillberg, A. Nordberg, B. Winblad, V. Sara

Research output: Contribution to journal › Article › peer-review

114 Citations (Scopus)

Abstract

The distribution of Insulin-like growth factor 1 (IGF-1) receptors in large cryosections of human brain hemispheres (80-μm) was studied by quantitative autoradiography using ¹²⁵I-IGF-1 as ligand. Postmortem tissue only from individuals free from neurological diseases was used. The highest densities of IGF-1 receptors were found in the hippocampus, amygdala and parahippocampal gyrus. Intermediate densities were observed in the cerebellum, cerebral cortex and caudate nucleus, whereas low densities of IGF-1 receptors were obtained in the substantia nigra, red nucleus, white matter and cerebral pedunculus. The cartography of IGF-1 receptors in the normal human brain will hopefully be of use in the study of the alteration of these receptors in diseased brain.

Original language	English
Pages (from-to)	299-303
Number of pages	5
Journal	Brain Research
Volume	503
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(89)91678-8
Publication status	Published - Dec 4 1989
Externally published	Yes

Keywords

Brain hemisphere
Human brain
Image analysis
Insulin-like growth factor-1
Large cryosection
Quantitative autoradiography
Receptor

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(89)91678-8

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title = "Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization",

abstract = "The distribution of Insulin-like growth factor 1 (IGF-1) receptors in large cryosections of human brain hemispheres (80-μm) was studied by quantitative autoradiography using 125I-IGF-1 as ligand. Postmortem tissue only from individuals free from neurological diseases was used. The highest densities of IGF-1 receptors were found in the hippocampus, amygdala and parahippocampal gyrus. Intermediate densities were observed in the cerebellum, cerebral cortex and caudate nucleus, whereas low densities of IGF-1 receptors were obtained in the substantia nigra, red nucleus, white matter and cerebral pedunculus. The cartography of IGF-1 receptors in the normal human brain will hopefully be of use in the study of the alteration of these receptors in diseased brain.",

keywords = "Brain hemisphere, Human brain, Image analysis, Insulin-like growth factor-1, Large cryosection, Quantitative autoradiography, Receptor",

author = "A. Adem and Jossan, {S. S.} and R. d'Argy and Gillberg, {P. G.} and A. Nordberg and B. Winblad and V. Sara",

note = "Funding Information: This study was supported by grants from Stiftelse for Gamla Tj~inarinnor, Hans and Loo Osterman's Foundation and The Swedish Medical Research Council.",

year = "1989",

month = dec,

day = "4",

doi = "10.1016/0006-8993(89)91678-8",

language = "English",

volume = "503",

pages = "299--303",

journal = "Brain Research",

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T1 - Insulin-like growth factor 1 (IGF-1) receptors in the human brain

T2 - quantitative autoradiographic localization

AU - Adem, A.

AU - Jossan, S. S.

AU - d'Argy, R.

AU - Gillberg, P. G.

AU - Nordberg, A.

AU - Winblad, B.

AU - Sara, V.

N1 - Funding Information: This study was supported by grants from Stiftelse for Gamla Tj~inarinnor, Hans and Loo Osterman's Foundation and The Swedish Medical Research Council.

PY - 1989/12/4

Y1 - 1989/12/4

N2 - The distribution of Insulin-like growth factor 1 (IGF-1) receptors in large cryosections of human brain hemispheres (80-μm) was studied by quantitative autoradiography using 125I-IGF-1 as ligand. Postmortem tissue only from individuals free from neurological diseases was used. The highest densities of IGF-1 receptors were found in the hippocampus, amygdala and parahippocampal gyrus. Intermediate densities were observed in the cerebellum, cerebral cortex and caudate nucleus, whereas low densities of IGF-1 receptors were obtained in the substantia nigra, red nucleus, white matter and cerebral pedunculus. The cartography of IGF-1 receptors in the normal human brain will hopefully be of use in the study of the alteration of these receptors in diseased brain.

AB - The distribution of Insulin-like growth factor 1 (IGF-1) receptors in large cryosections of human brain hemispheres (80-μm) was studied by quantitative autoradiography using 125I-IGF-1 as ligand. Postmortem tissue only from individuals free from neurological diseases was used. The highest densities of IGF-1 receptors were found in the hippocampus, amygdala and parahippocampal gyrus. Intermediate densities were observed in the cerebellum, cerebral cortex and caudate nucleus, whereas low densities of IGF-1 receptors were obtained in the substantia nigra, red nucleus, white matter and cerebral pedunculus. The cartography of IGF-1 receptors in the normal human brain will hopefully be of use in the study of the alteration of these receptors in diseased brain.

KW - Brain hemisphere

KW - Human brain

KW - Image analysis

KW - Insulin-like growth factor-1

KW - Large cryosection

KW - Quantitative autoradiography

KW - Receptor

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C2 - 2557967

AN - SCOPUS:0024347261

SN - 0006-8993

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JO - Brain Research

JF - Brain Research

IS - 2

ER -

Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization

Abstract

Keywords

ASJC Scopus subject areas

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