TY - JOUR
T1 - Integration of salmonella into combination cancer therapy
AU - Al-Saafeen, Besan H.
AU - Fernandez-Cabezudo, Maria J.
AU - Al-Ramadi, Basel K.
N1 - Funding Information:
Funding: Work in Dr Al-Ramadi’s laboratory is supported by grants from the Terry Fox Foundation (#I1030), the Sheikh Hamdan Award for Medical Sciences (MRG/107/2018), the Zayed Center for Health Sciences (#31R088 and #31R189), the UAEU Program for Advanced Research (#31M193), and the Research Grants Committee (#NP-15-02), College of Medicine and Health Sciences, United Arab Emirates University (to B.K. a-R).
Funding Information:
Acknowledgments: The authors wish to acknowledge United Arab Emirates University, the Shiekh Hamdan Award for Medical Sciences, and the Terry Fox Foundation for supporting this project. B.H.A.-S. is supported by a student scholarship from the Office of Graduate Studies, College of Medicine and Health Sciences, United Arab Emirates University (Al Ain, United Arab Emirates).
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - Current modalities of cancer treatment have limitations related to poor target selectivity, resistance to treatment, and low response rates in patients. Accumulating evidence over the past few decades has demonstrated the capacity of several strains of bacteria to exert anti-tumor activities. Salmonella is the most extensively studied entity in bacterial-mediated cancer therapy, and has a good potential to induce direct tumor cell killing and manipulate the immune components of the tumor microenvironment in favor of tumor inhibition. In addition, Salmonella possesses some advantages over other approaches of cancer therapy, including high tumor specificity, deep tissue penetration, and engineering plasticity. These aspects underscore the potential of utilizing Salmonella in combination with other cancer therapeutics to improve treatment effectiveness. Herein, we describe the advantages that make Salmonella a good candidate for combination cancer therapy and summarize the findings of representative studies that aimed to investigate the therapeutic outcome of combination therapies involving Salmonella. We also highlight issues associated with their application in clinical use.
AB - Current modalities of cancer treatment have limitations related to poor target selectivity, resistance to treatment, and low response rates in patients. Accumulating evidence over the past few decades has demonstrated the capacity of several strains of bacteria to exert anti-tumor activities. Salmonella is the most extensively studied entity in bacterial-mediated cancer therapy, and has a good potential to induce direct tumor cell killing and manipulate the immune components of the tumor microenvironment in favor of tumor inhibition. In addition, Salmonella possesses some advantages over other approaches of cancer therapy, including high tumor specificity, deep tissue penetration, and engineering plasticity. These aspects underscore the potential of utilizing Salmonella in combination with other cancer therapeutics to improve treatment effectiveness. Herein, we describe the advantages that make Salmonella a good candidate for combination cancer therapy and summarize the findings of representative studies that aimed to investigate the therapeutic outcome of combination therapies involving Salmonella. We also highlight issues associated with their application in clinical use.
KW - Cancer
KW - Combination therapy
KW - Immunotherapy
KW - Salmonella
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U2 - 10.3390/cancers13133228
DO - 10.3390/cancers13133228
M3 - Review article
AN - SCOPUS:85108690628
SN - 2072-6694
VL - 13
JO - Cancers
JF - Cancers
IS - 13
M1 - 3228
ER -