Interactions of nabumetone with γ-cyclodextrin studied by fluorescence measurements

Nathir A.F. Al-Rawashdeh

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The inclusion of the anti-inflammatory drug, Nabumetone (NAB), in γ-cyclodextrin (γ-CD) was studied by fluorescence measurements. The emission fluorescence spectrum, of NAB reveals a maximum whose intensity increases with the different γ-CD's growing concentrations. The stoichiometery (1:1) and binding constants of the complexes at 15, 25, 35, and 45°C were extracted from the analysis of the emission spectra of NAB. The thermodynamic parameters ΔH° and ΔS° for the formation of the complex were calculated from the temperature dependence of the binding constants and compared with previous results for similar complexes of NAB with α- and β-CDs. The location of NAB in the complex was determined using the fluorescence quenching method. Our results indicate that NAB is completely penetrated into the cavity of γ-CD.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalJournal of Inclusion Phenomena
Volume51
Issue number1
DOIs
Publication statusPublished - Feb 2005
Externally publishedYes

Keywords

  • Fluorescence
  • Inclusion complexes
  • Nabumetone
  • γ-cyclodextrin

ASJC Scopus subject areas

  • Food Science
  • General Chemistry
  • Condensed Matter Physics

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