Interrelation between the poisoning severity score, carboxyhaemoglobin levels and in-hospital clinical course of carbon monoxide poisoning

Arif Alper Cevik, I. Unluoglu, S. Yanturali, S. Kalkan, A. Sahin

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

The aim of the present study is to evaluate the relationship between the Poisoning Severity Score (PSS) and carboxyhaemoglobin (COHb) levels in patients with carbon monoxide poisoning (COP) using outcome as the measure. The study was designed as a retrospective chart review of patients with final diagnosis of COP. Correlation of PSS and COHb levels at presentation was evaluated with collected data. Majority of the cases were grade 1 (minor) PSS (134 cases, 73.6%) and 93.4% of these patients made a complete recovery. There were six deaths (mortality 3.3%) and six in-hospital major complications (IHMCs) (3.3%). Pathologies that cause mortality included acute renal failure in 3 patients, cerebral ischemia in 2 patients and cardiac ischemia with rhythm problem in a patient. There is moderate correlation between PSS and outcome (p < 0.001, r = 0.493). Grade 3 (severe) PSS was significantly different from other grades for outcome (six mortalities and three IHMCs). Patients classified as grade 3 and patients who died had a significantly higher mean age (p < 0.05, 41.8 ± 23.6 and p < 0.01, 60.1 ± 20.3, respectively). Mean COHb level of grade 3 (33.2 ± 13.9%) was significantly higher than that of other grades (p < 0.05). COHb levels according to outcome were not different between PSS grades. Decreased level of consciousness, acidosis, tachycardia, high glucose and leucocyte levels showed significant relation with higher PSS, COHb level and adverse outcome. We conclude that the PSS is a reliable guide in COP. Value of the PSS in COP may be enhanced if additional factors and investigations are include.

Original languageEnglish
Pages (from-to)1558-1564
Number of pages7
JournalInternational Journal of Clinical Practice
Volume60
Issue number12
DOIs
Publication statusPublished - Dec 2006
Externally publishedYes

Keywords

  • Carbon monoxide
  • Emergency
  • Poisoning
  • Poisoning Severity Score

ASJC Scopus subject areas

  • General Medicine

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