Intracellular stores and calcium signalling in mammalian sensory neurones

P. G. Kostyuk, A. V. Shmigol

Research output: Contribution to journalConference articlepeer-review

10 Citations (Scopus)


The:injection of Ca ions into the cytoplasm through coordinated activity of calcium-permeable channels in the surface membrane and the membranes of intracellular organelles is the main source of temporary elevation of the cytoplasmic free Ca2+ level ('the calcium signal') which triggers cellular responses to various stimuli. In our experiments the contribution of intracellular Ca2+ stores to calcium signal generation was studied in two subpopulations of dorsal root ganglion (DRG) neurones using a combination of patch-clamp technique for measuring transmembrane currents and fluorescent indicator indo-1 for estimating the changes in the cytoplasmic free Ca2+ level. Ca-induced Ca2+ release (CICR) and inositol(1,4,5)-triphosphate (IP3)-induced Ca2+ release (IICR) were found to be functional only in certain types of sensory neuronal cell, presumably in neurones transmitting tactile and proprioceptive information. Mitochondrial Ca2+ accumulation and release was found to participate in the shaping of calcium signals in both subpopulations of DRG neurones.

Original languageEnglish
Pages (from-to)197-205
Number of pages9
JournalBioelectrochemistry and Bioenergetics
Issue number2
Publication statusPublished - May 1997
Externally publishedYes
EventProceedings of the 1996 13th International Symposium on Bioelectrochemistry and Bioenergetics - Ein Gedi, Isr
Duration: Jan 7 1996Jan 12 1996


  • Calcium signalling
  • Sensory neurones

ASJC Scopus subject areas

  • Biophysics
  • Physical and Theoretical Chemistry
  • Electrochemistry


Dive into the research topics of 'Intracellular stores and calcium signalling in mammalian sensory neurones'. Together they form a unique fingerprint.

Cite this