Intracerebroventricular administration of somatostatin prevents and attenuates adjuvant arthritis

Adlan M. Elhassan, Abdu Adem, Nikos Papadogiannakis, Isam Suliman, Adel Gad, J. Urban Lindgren

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


The effects of somatostatin on the development of adjuvant arthritis induced by Mycobacterium butyricum were studied. Somatostatin was injected into the lateral cerebral ventricle every day for 14 days beginning on the first day of mycobacteria inoculation in the preventive group. In the treatment group, somatostatin was injected from day 17 until day 30 post-mycobacteria inoculation. Arthritis was evaluated by measuring ankle joint circumference and diameter as well as microscopic examination of ankle joint sections. Somatostatin profoundly inhibited the development of adjuvant arthritis and an anti-inflammatory action was observed in the treatment group. These results suggest that somatostatin has a central action that can prevent or attenuate symptoms associated with arthritis.

Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalJournal of Neuroimmunology
Issue number1
Publication statusPublished - May 1 2001


  • Adjuvant
  • Arthritis
  • Somatostatin
  • Synovium

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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