Intricate relationship between adaptive and innate immune system in allergic contact dermatitis

Muhammad Azeem, Hidaya Kader, Andreas Kerstan, Helal F. Hetta, Edgar Serfling, Matthias Goebeler, Khalid Muhammad

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)


Allergic contact dermatitis (ACD) is a complex immunological allergic disease characterized by the interplay between the innate and adaptive immune system. Initially, the role of the innate immune system was believed to be confined to the initial sensitization phase, while adaptive immune reactions were linked with the advanced elicitation phase. However, recent data predicted a comparatively mixed and interdependent role of both immune systems throughout the disease progression. Therefore, the actual mechanisms of disease progression are more complex and interlinked. The aim of this review is to combine such findings that enhanced our understanding of the pathomechanisms of ACD. Here, we focused on the main cell types from both immune domains, which are involved in ACD, such as CD4+ and CD8+ T cells, B cells, neutrophils, and innate lymphoid cells (ILCs). Such insights can be useful for devising future therapeutic interventions for ACD.

Original languageEnglish
Pages (from-to)699-709
Number of pages11
JournalYale Journal of Biology and Medicine
Issue number5
Publication statusPublished - Dec 2020


  • Adaptive immune cells
  • Allergic contact dermatitis
  • Innate immune cells
  • Lymphocytes

ASJC Scopus subject areas

  • General Medicine


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