Introducing cichorium pumilum as a potential therapeutical agent against drug-induced benign breast tumor in rats

M. Ali H. Al-Akhras, Khaled Aljarrah, Hasan Al-Khateeb, Adnan Jaradat, Abdelkarim Al-Omari, Amjad Al-Nasser, Majed M. Masadeh, Amr Amin, Alaaeldin Hamza, Karima Mohammed, Mohammad Al Olama, Sayel Daoud

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Cichorium Pumilum (chicory) is could be a promising cancer treatment in which a photosensitizing drug concentrates in benign tumor cells and activated by quanta at certain wavelength. Such activated extracts could lead to cell death and tumor ablation. Previous studies have shown that Cichorium Pumilum (chicory) contains photosensitive compounds such as cichoriin, anthocyanins, lactucin, and Lactucopicrin. In the present study, the protective effect of sun light-activated Cichorium against the dimethylbenz[a]anthracene (DMBA) induced benign breast tumors to female Sprague-Dawley rats was investigated. Chicory's extract has significantly increase P.carbonyl (PC) and malondialdehyde (MDA) and decreases the hepatic levels of total antioxidant capacity (TAC) and superoxide dismutase (SOD) in benign breast tumors-induced group compared to control. It also significantly decrease the number of estrogen receptors ER-positive cells in tumor masses. These results suggest that chicory extracts could be used as herbal photosensitizing agent in treating benign breast tumor in rats.

Original languageEnglish
Pages (from-to)299-309
Number of pages11
JournalElectromagnetic Biology and Medicine
Volume31
Issue number4
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Benign breast tumor
  • Chicory
  • Oxidative stress
  • Photohemolysis

ASJC Scopus subject areas

  • Biophysics
  • Medicine (miscellaneous)

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