TY - JOUR
T1 - Invasive fungal infections are associated with severe depletion of circulating RANTES
AU - Ellis, Michael
AU - Al-Ramadi, Basel
AU - Hedström, Ulla
AU - Alizadeh, Hussain
AU - Shammas, Victor
AU - Kristensen, Jörgen
PY - 2005/11
Y1 - 2005/11
N2 - Serum RANTES (regulated on activation, normal T-cell expressed and secreted) concentrations were measured in 14 patients who had haematological malignancies and developed invasive fungal infections (three of them definite, eight probable and three possible). RANTES levels fell substantially from pre-chemotherapy values at the start of and throughout the fungal infection, and recovered in patients who survived the fungal infection. However, in patients who died from the invasive fungal infection, RANTES levels did not recover. For survivors the mean ± SD levels for RANTES were 7656 ± 877 pg ml-1 on the day prior to chemotherapy, 3723 ± 2443 pg ml -1 on the first day of fungal infection diagnosis (significantly different from baseline; P = 0.001) and 9078 ± 2256 pg ml-1 at recovery from the fungal infection (significantly different from lowest value; P < 0.0001). Platelet counts were closely correlated with the RANTES levels (r = 0.63, P < 0.001). The RANTES concentrations for the three patients who died were similar to those who survived at all equivalent timepoints, but were significantly lower at the time of death (792 ± 877) compared to the values at recovery for survivors (P = 0.005). The finding that patients who died from an invasive fungal infection had very low platelet counts and RANTES concentrations suggests that these could play a role in host response to such infections.
AB - Serum RANTES (regulated on activation, normal T-cell expressed and secreted) concentrations were measured in 14 patients who had haematological malignancies and developed invasive fungal infections (three of them definite, eight probable and three possible). RANTES levels fell substantially from pre-chemotherapy values at the start of and throughout the fungal infection, and recovered in patients who survived the fungal infection. However, in patients who died from the invasive fungal infection, RANTES levels did not recover. For survivors the mean ± SD levels for RANTES were 7656 ± 877 pg ml-1 on the day prior to chemotherapy, 3723 ± 2443 pg ml -1 on the first day of fungal infection diagnosis (significantly different from baseline; P = 0.001) and 9078 ± 2256 pg ml-1 at recovery from the fungal infection (significantly different from lowest value; P < 0.0001). Platelet counts were closely correlated with the RANTES levels (r = 0.63, P < 0.001). The RANTES concentrations for the three patients who died were similar to those who survived at all equivalent timepoints, but were significantly lower at the time of death (792 ± 877) compared to the values at recovery for survivors (P = 0.005). The finding that patients who died from an invasive fungal infection had very low platelet counts and RANTES concentrations suggests that these could play a role in host response to such infections.
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U2 - 10.1099/jmm.0.46121-0
DO - 10.1099/jmm.0.46121-0
M3 - Article
C2 - 16192431
AN - SCOPUS:27644535852
SN - 0022-2615
VL - 54
SP - 1017
EP - 1022
JO - Journal of Medical Microbiology
JF - Journal of Medical Microbiology
IS - 11
ER -