Investigating the Potential Therapeutic Mechanisms of Puerarin in Neurological Diseases

Payal Chauhan, Karan Wadhwa, Richa Mishra, Saurabh Gupta, Fuzail Ahmad, Mehnaz Kamal, Danish Iqbal, Mohammed Alsaweed, Mohana Vamsi Nuli, Mosleh Mohammad Abomughaid, Abdulmajeed G. Almutary, Prabhu Chandra Mishra, Saurabh Kumar Jha, Shreesh Ojha, Vinod Kumar Nelson, Abha Dargar, Govind Singh, Niraj Kumar Jha

Research output: Contribution to journalReview articlepeer-review

Abstract

Plants and their derived phytochemicals have a long history of treating a wide range of illnesses for several decades. They are believed to be the origin of a diverse array of medicinal compounds. One of the compounds found in kudzu root is puerarin, a isoflavone glycoside commonly used as an alternative medicine to treat various diseases. From a biological perspective, puerarin can be described as a white needle crystal with the chemical name of 7-hydroxy-3-(4-hydroxyphenyl)-1-benzopyran-4-one-8-D-glucopyranoside. Besides, puerarin is sparingly soluble in water and produces no color or light yellow solution. Multiple experimental and clinical studies have confirmed the significant therapeutic effects of puerarin. These effects span a wide range of pharmacological effects, including neuroprotection, hepatoprotection, cardioprotection, immunomodulation, anticancer properties, anti-diabetic properties, anti-osteoporosis properties, and more. Puerarin achieves these effects by interacting with various cellular and molecular pathways, such as MAPK, AMPK, NF-κB, mTOR, β-catenin, and PKB/Akt, as well as different receptors, enzymes, and growth factors. The current review highlights the molecular mechanism of puerarin as a neuroprotective agent in the treatment of various neurodegenerative and neurological diseases. Extensive cellular, animal, and clinical research has provided valuable insights into its effectiveness in conditions such as Alzheimer’s disease, Parkinson’s disease, epilepsy, cerebral stroke, depression, and more.

Original languageEnglish
JournalMolecular Neurobiology
DOIs
Publication statusAccepted/In press - 2024

Keywords

  • Medicinal plant (Pueraria lobata)
  • Neurodegeneration
  • Neuroprotective effect
  • Neurotherapeutics
  • Puerarin
  • Signaling molecules

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Neurology
  • Cellular and Molecular Neuroscience

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