Investigation into the prophylactic and therapeutic activity of coenzyme Q10 against COVID-19

Ali AL-Samydai, Maha N. Abu Hajleh, Amal Akour, Naeem Shalan, Nisrein Jaber, Lidia Kamal Al-Halaseh, Muhammed Alzweiri

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To evaluate the anti-SARS CoV-2 effect of Coenzyme Q 10, Ubiquinol-10, and idebenone, which have beneficial therapeutic applications against diverse virus types, using molecular docking approach. Methods: The potential activity of Coenzyme Q10, Ubiquinol-10, and Idebenone against viral infections was explored through the collection of data from relevant literature, and by modelling these compounds virtually, using in silico investigation methods. Results: Coenzyme Q10 and ubiquinol-10 showed significant docking performance. They interacted with numerous amino acid residues of the main protease of SARS-CoV-2 ACE2 (7C8J), Alpha thrombin (1AE8), TYRO (4TS1) protein targets sides, SARS-coronavirus Orf7a accessory protein (1XAK), TNF (1RJ8), and Cytokine/receptor (1I1R). Conclusion: The findings of our study showed promising inhibitory activities of the selected compounds against the main proteases of SARS-CoV-2. Consequently, these compounds have theoretical effects on inhibiting the viral entry, reproduction, and ultimately the prevention and/or treatment of the SARSCoV2 infection.

Original languageEnglish
Pages (from-to)2387-2393
Number of pages7
JournalTropical Journal of Pharmaceutical Research
Volume20
Issue number11
DOIs
Publication statusPublished - Nov 2021
Externally publishedYes

Keywords

  • Coenzyme Q10
  • Docking
  • Idebenone
  • SARS-CoV-2
  • Ubiquinol-10

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology (medical)

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