TY - JOUR
T1 - Investigation of fatty acid profile of eyes recovered from slaughterhouse waste
AU - Hachem, Mayssa
AU - Bermudez, J. Rafael
AU - Ali, Abdelmoneim H.
AU - Murtaza, Fiza F.
AU - Rommala, Mohan
AU - Corridon, Peter R.
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/9/30
Y1 - 2024/9/30
N2 - Polyunsaturated fatty acids (PUFAs), principally Docosahexaenoic acid (DHA, 22:6n-3), the foremost omega-3 PUFAs in the brain and eyes, have been implicated in maintaining the structural and functional properties of the retina and cornea. Another PUFA, Arachidonic Acid (AA, 20:4n-6), primary omega-6 PUFA in the cell membrane of phospholipids, is a central inflammatory mediator involved in many molecular and cellular functions under physiological and pathological conditions, including dry eye disease (DED) and age-related macular degeneration (AMD). This study investigated the fatty acids (FA) composition of the vitreous humor, retina, cornea, and whole eye in two mammals, the Arabian sheep (Ovis aries) and Arabian camel (Camelus dromedarius), with the aim of exploring new paths for beneficial PUFA production. In Ovis aries, the retina exhibited the highest content in DHA and AA with 4.30 ± 0.63 % and 13.48 ± 1.33 % of the total fatty acid content, respectively. In Camelus dromedarius, the DHA content was greater in the retina compared to all samples, and AA was detected in the vitreous humor, cornea, retina, and whole eye, with the highest content in the retina (15.38 ± 0.71 %). Comparing both mammals, the DHA fraction was higher in camel's retina than in sheep's retina, whereas no differences were noticed for AA accumulation. In conclusion, ocular tissues collected from agri-food waste in slaughterhouses could serve as a sustainable source for FA production and provide an innovative and emerging prospect in the nutrition, pharmaceutical, and healthcare sectors.
AB - Polyunsaturated fatty acids (PUFAs), principally Docosahexaenoic acid (DHA, 22:6n-3), the foremost omega-3 PUFAs in the brain and eyes, have been implicated in maintaining the structural and functional properties of the retina and cornea. Another PUFA, Arachidonic Acid (AA, 20:4n-6), primary omega-6 PUFA in the cell membrane of phospholipids, is a central inflammatory mediator involved in many molecular and cellular functions under physiological and pathological conditions, including dry eye disease (DED) and age-related macular degeneration (AMD). This study investigated the fatty acids (FA) composition of the vitreous humor, retina, cornea, and whole eye in two mammals, the Arabian sheep (Ovis aries) and Arabian camel (Camelus dromedarius), with the aim of exploring new paths for beneficial PUFA production. In Ovis aries, the retina exhibited the highest content in DHA and AA with 4.30 ± 0.63 % and 13.48 ± 1.33 % of the total fatty acid content, respectively. In Camelus dromedarius, the DHA content was greater in the retina compared to all samples, and AA was detected in the vitreous humor, cornea, retina, and whole eye, with the highest content in the retina (15.38 ± 0.71 %). Comparing both mammals, the DHA fraction was higher in camel's retina than in sheep's retina, whereas no differences were noticed for AA accumulation. In conclusion, ocular tissues collected from agri-food waste in slaughterhouses could serve as a sustainable source for FA production and provide an innovative and emerging prospect in the nutrition, pharmaceutical, and healthcare sectors.
KW - Arachidonic acid
KW - Biotechnological process
KW - Docosahexaenoic acid
KW - Fatty acid extraction
KW - Mammal eyes
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U2 - 10.1016/j.heliyon.2024.e38148
DO - 10.1016/j.heliyon.2024.e38148
M3 - Article
AN - SCOPUS:85204475259
SN - 2405-8440
VL - 10
JO - Heliyon
JF - Heliyon
IS - 18
M1 - e38148
ER -