Involvement of capsaicin sensitive primary afferents in thymulin- induced hyperalgesia

Nayef E. Saadé; Stella C. Major; Suhayl J. Jabbur; Samir F. Atweh; Salim A. Kanaan; Bared Safieh-Garabedian

doi:10.1016/S0165-5728(98)00176-3

Involvement of capsaicin sensitive primary afferents in thymulin- induced hyperalgesia

Nayef E. Saadé, Stella C. Major, Suhayl J. Jabbur, Samir F. Atweh, Salim A. Kanaan, Bared Safieh-Garabedian

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Intraplantar (5 ng) or intraperitoneal (50 ng) injections of thymulin, produced both thermal and mechanical hyperalgesia in rats. In this report, we show that ablation of capsaicin sensitive primary afferents (CSPA) can alter or abolish thymulin-induced hyperalgesia. Different groups of rats were subjected to either treatment with capsaicin or to surgical subdiaphragmatic vagotomy (SDV). Both capsaicin and SDV reduced significantly thymulin- induced hyperalgesia. On the other hand, these treatments elicited differential effects on the modulation by thymulin of the levels of nerve growth factor and interleukin 1β. We conclude that the hyperalgesic effects of i.p. thymulin are mainly mediated through the CSPA fibers.

Original language	English
Pages (from-to)	171-179
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	91
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(98)00176-3
Publication status	Published - Nov 2 1998
Externally published	Yes

Keywords

Capsaicin
Hyperalgesia
NGF, interleukin
Thymulin
Vagus

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/S0165-5728(98)00176-3

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title = "Involvement of capsaicin sensitive primary afferents in thymulin- induced hyperalgesia",

abstract = "Intraplantar (5 ng) or intraperitoneal (50 ng) injections of thymulin, produced both thermal and mechanical hyperalgesia in rats. In this report, we show that ablation of capsaicin sensitive primary afferents (CSPA) can alter or abolish thymulin-induced hyperalgesia. Different groups of rats were subjected to either treatment with capsaicin or to surgical subdiaphragmatic vagotomy (SDV). Both capsaicin and SDV reduced significantly thymulin- induced hyperalgesia. On the other hand, these treatments elicited differential effects on the modulation by thymulin of the levels of nerve growth factor and interleukin 1β. We conclude that the hyperalgesic effects of i.p. thymulin are mainly mediated through the CSPA fibers.",

keywords = "Capsaicin, Hyperalgesia, NGF, interleukin, Thymulin, Vagus",

author = "Saad{\'e}, {Nayef E.} and Major, {Stella C.} and Jabbur, {Suhayl J.} and Atweh, {Samir F.} and Kanaan, {Salim A.} and Bared Safieh-Garabedian",

note = "Funding Information: The authors thank John Haddad, Raffy H. Jalakhian and Riad Maalouf for their technical assistance in this study. This research was funded in part by the University Research Board.",

year = "1998",

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doi = "10.1016/S0165-5728(98)00176-3",

language = "English",

volume = "91",

pages = "171--179",

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T1 - Involvement of capsaicin sensitive primary afferents in thymulin- induced hyperalgesia

AU - Saadé, Nayef E.

AU - Major, Stella C.

AU - Jabbur, Suhayl J.

AU - Atweh, Samir F.

AU - Kanaan, Salim A.

AU - Safieh-Garabedian, Bared

N1 - Funding Information: The authors thank John Haddad, Raffy H. Jalakhian and Riad Maalouf for their technical assistance in this study. This research was funded in part by the University Research Board.

PY - 1998/11/2

Y1 - 1998/11/2

N2 - Intraplantar (5 ng) or intraperitoneal (50 ng) injections of thymulin, produced both thermal and mechanical hyperalgesia in rats. In this report, we show that ablation of capsaicin sensitive primary afferents (CSPA) can alter or abolish thymulin-induced hyperalgesia. Different groups of rats were subjected to either treatment with capsaicin or to surgical subdiaphragmatic vagotomy (SDV). Both capsaicin and SDV reduced significantly thymulin- induced hyperalgesia. On the other hand, these treatments elicited differential effects on the modulation by thymulin of the levels of nerve growth factor and interleukin 1β. We conclude that the hyperalgesic effects of i.p. thymulin are mainly mediated through the CSPA fibers.

AB - Intraplantar (5 ng) or intraperitoneal (50 ng) injections of thymulin, produced both thermal and mechanical hyperalgesia in rats. In this report, we show that ablation of capsaicin sensitive primary afferents (CSPA) can alter or abolish thymulin-induced hyperalgesia. Different groups of rats were subjected to either treatment with capsaicin or to surgical subdiaphragmatic vagotomy (SDV). Both capsaicin and SDV reduced significantly thymulin- induced hyperalgesia. On the other hand, these treatments elicited differential effects on the modulation by thymulin of the levels of nerve growth factor and interleukin 1β. We conclude that the hyperalgesic effects of i.p. thymulin are mainly mediated through the CSPA fibers.

KW - Capsaicin

KW - Hyperalgesia

KW - NGF, interleukin

KW - Thymulin

KW - Vagus

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ER -

Involvement of capsaicin sensitive primary afferents in thymulin- induced hyperalgesia

Abstract

Keywords

ASJC Scopus subject areas

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