Is Hashimoto’s thyroiditis a risk factor for medullary thyroid carcinoma? Our experience and a literature review

Ayman A. Zayed, Moaath K.Mustafa Ali, Omar I. Jaber, Moh’d J. Suleiman, Ashraf A. Ashhab, Wajdi Mohammed Al Shweiat, Munther Suliaman Momani, Maha Shomaf, Salah Mohammed AbuRuz

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The etiology of medullary thyroid carcinoma remains unknown. The aim of this study was to determine whether there is a significant association between medullary thyroid carcinoma and Hashimoto’s thyroiditis in the histopathologic material of thyroidectomized patients. Retrospective cross-sectional study. In this study, we reviewed the medical records of all patients who underwent total thyroidectomy for different thyroid-related complaints between January 2000 and January 2012 at Jordan University Hospital—Amman, Jordan. To highlight relevant previously published studies addressing this topic, a literature search was conducted for English language studies reporting “medullary thyroid carcinoma” or “C-cell hyperplasia” in patients with Hashimoto’s thyroiditis. Of the 863 patients with a mean age of 47.2 ± 12.3 years who underwent total thyroidectomy during the study period, 78 (9.04 %) were diagnosed with Hashimoto’s thyroiditis, and 15 (1.74 %) had medullary thyroid carcinoma, 3 (20 %) of whom had coexistent Hashimoto’s thyroiditis. A total of 683 (79.1 %) patients had benign thyroid disease, 67 (9.8 %) of whom had Hashimoto’s thyroiditis. The difference between these rates was not statistically significant (p = 0.19). When examined by gender, 9 females had medullary thyroid carcinoma, 3 (33.3 %) of whom had coexistent Hashimoto’s thyroiditis; by contrast, of 560 females with benign thyroid disease, 62 (11.1 %) had Hashimoto’s thyroiditis (p = 0.04). Although this study population represents a small and single-institution experience, our results suggest that there might be an association between Hashimoto’s thyroiditis and medullary thyroid carcinoma only in female patients who undergo total thyroidectomy.

Original languageEnglish
Pages (from-to)629-636
Number of pages8
JournalEndocrine
Volume48
Issue number2
DOIs
Publication statusPublished - Mar 2015
Externally publishedYes

Keywords

  • Hashimoto’s thyroiditis
  • Jordan
  • Medullary thyroid carcinoma
  • Thyroidectomy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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