Is Rh positivity a possible risk factor for lung cancer?

Mohammad Alqudah, Mohammed Allouh, Shadi Hamouri, Anas Zaitoun, Nawwaf Al ghamdi, Tariq N. Aladily, Khalid Kheirallah, Haitham Qandeel, Maha Al-Keilani, Rola Subhi Saqan, Ismail Matalka

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


The association between ABO and Rh blood groups and the incidence of various types of cancers has been previously investigated, but with no definite consensus reached. Since lung cancer has become one of the most leading causes of cancer-related deaths, its relation to ABO/Rh is being investigated in many centers. To explore the relationship between ABO and Rh blood groups and the risk of lung cancer. A case control study was conducted to explore the relationship between blood groups/Rh factor and the risk of lung cancer. Lung cancer cases (n=458) were identified from two major university hospitals. Control subjects included a total of 3,847 patients in which none is a cancer patient. ABO and Rh blood groups were typed and compared between cases and controls. The adjusted effect of Rh, but not ABO blood group, was significantly associated with the risk of lung cancer. The results of this study showed that Rh positive subjects are more likely to have lung cancer than the Rh negative subjects, indicating an association between Rh positivity and the risk of lung cancer. The Rh factor showed a significant association with lung cancer, but not with ABO blood groups. Further studies are needed to investigate this association to determine the role of Rh in the development of lung cancer.

Original languageEnglish
Pages (from-to)281-284
Number of pages4
JournalJordan Journal of Biological Sciences
Issue number3
Publication statusPublished - 2018
Externally publishedYes


  • Blood group
  • Cancer
  • Jordan
  • Lung
  • Rh

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Agricultural and Biological Sciences


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