Is the 21-gene recurrence score a cost-effective assay in endocrine-sensitive node-negative breast cancer?

Nathan W.D. Lamond, Chris Skedgel, Tallal Younis

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

The 21-gene recurrence score (RS) is a gene expression profile assay currently endorsed for use in patients with endocrine-sensitive node-negative breast cancers. The RS has been shown to augment current 'prognostic' and 'predictive' assessments of relapse risk and chemotherapy benefits, respectively, and lead to significant change in oncologists' recommendations for adjuvant chemotherapy, with an overall reduction in chemotherapy utilization. The RS (Oncotype DX®) is marketed by Genomic Health Inc. (CA, USA) and currently retails for approximately US$4290 per patient. Like all novel tests/therapies, however, these upfront costs should be examined in the context of all its clinical benefits through cost-effectiveness or cost-utility evaluations. This review highlights the clinical evidence supporting RS testing for patients with endocrine-sensitive node-negative breast cancers, and examines all published economic evaluations that examined its 'value for money' in this setting.

Original languageEnglish
Pages (from-to)243-250
Number of pages8
JournalExpert Review of Pharmacoeconomics and Outcomes Research
Volume13
Issue number2
DOIs
Publication statusPublished - Apr 2013
Externally publishedYes

Keywords

  • 21-gene recurrence score
  • breast cancer
  • cost-effectiveness
  • cost-utility
  • gene expression

ASJC Scopus subject areas

  • Health Policy
  • Pharmacology (medical)

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