Ketogenic diet and cognition in neurological diseases: A systematic review

S. Pavón, E. Lázaro, O. Martínez, I. Amayra, J. F. López-Paz, P. Caballero, M. Al-Rashaida, P. M. Luna, M. García, M. Pérez, S. Berrocoso, A. A. Rodríguez, P. Pérez-Núñez

Research output: Contribution to journalReview articlepeer-review

29 Citations (Scopus)


Context: In recent years, the ketogenic diet has gained special relevance as a possible therapeutic alternative to some neurological and chronic diseases. Objective: The aim of this systematic review was to answer the following question: Does a ketogenic diet improve cognitive skills in patients with Alzheimer's disease, Parkinson's disease, refractory epilepsy, and type 1 glucose deficiency syndrome? To define the research question, the PICOS criteria were used, following the guidelines of the PRISMA method. Data sources: Medline/PubMed, Elsevier Science Direct, Dialnet, EBSCOhost, Mediagraphic, Sage Journals, ProQuest, and Wiley Online Library databases were used. Data extraction: After applying inclusion and exclusion criteria in accordance with the PRISMA method, a total of 63 entries published between 2004 and 2019 were used. Data analysis: The records extracted were analyzed from a qualitative approach, so no statistical analysis was carried out. Conclusion: Although scientific literature on the subject is scarce and there has tended to be a lack of scientific rigor, the studies reviewed confirmed the effectiveness of this diet in improving the cognitive symptomatology of the aforementioned diseases.

Original languageEnglish
Pages (from-to)802-813
Number of pages12
JournalNutrition Reviews
Issue number7
Publication statusPublished - Jul 1 2021
Externally publishedYes


  • Alzheimer's disease
  • Parkinson's disease
  • cognition
  • glucose transporter deficiency syndrome type 1
  • ketogenic diet
  • ketosis
  • low carbohydrate diet
  • refractory epilepsy
  • β-hydroxybutyrate

ASJC Scopus subject areas

  • General Medicine


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