L-2-Oxothiazolidine-4-carboxylic acid mitigates the thromboembolic effects and systemic toxicity induced by sub-acute exposure to cadmium in mice

Exposure to cadmium (Cd) as a result of its environmental pervasiveness poses deleterious health effects, which has been attributed to oxidative stress. Therefore, this study aims to examine the sub-acute (1 mg Cd/kg/day, i.p., for 3 weeks) systemic and thrombotic influence of Cd exposure in vivo, and to assess the protective effects of the antioxidant L-2-Oxothiazolidine-4-Carboxylic acid (OTC, 80 mg/kg/day, i.p.). Cd compared with control group significantly reduced both the time for the first platelet aggregate and until blood flow stopped in pial microvessels. OTC significantly increased both the time for the first aggregate and until flow stopped. Cd induced a significant increase in total WBC, CK, AST, and LDH. The antioxidants SOD and catalase activities significantly increased in mice treated with Cd. OTC, through its antioxidant actions, appeared to effectively protect Cd induced thrombosis in mice. Hence, OTC represents a potential protective candidate from the detrimental effect of Cd toxicity.