Abstract
Objective: To explore the effect of INF α-2b on oxygen consumption of endometrioma cells in culture. Design: Oxygen consumption is evaluated by the use of phosphorimeter, which measures oxygen concentration in solution. Patients: A sample of endometrioma from patients who had undergone surgery for such disease, was cultured to develop cell lines for this study. Results: INF α-2b (at 4,000 units/ml) inhibited the proliferation of endometrioma cells in culture. The curves that describe [O2] in the cell suspensions as function of time, were linear, indicating that the kinetics were zero order. INF α-2b had unnoticeable effect on the cellular oxygen consumption. Conclusion: INF α-2b treatment does not target the energy converting mechanism in the mitochondria. Its antiproliferative effect may be related to inhibition of intracellular DNA.
Original language | English |
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Pages (from-to) | 251-255 |
Number of pages | 5 |
Journal | Middle East Fertility Society Journal |
Volume | 9 |
Issue number | 3 |
Publication status | Published - 2004 |
Externally published | Yes |
Keywords
- Endometrioma
- Interferon α-2b
- O consumption
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology