Lack of effect of pancreatic polypeptide in the rate of gastric emptying and gut hormone release during breakfast

T. E. Adrian; G. R. Greenberg; M. L. Fitzpatrick; S. R. Bloom

doi:10.1159/000198565

Lack of effect of pancreatic polypeptide in the rate of gastric emptying and gut hormone release during breakfast

T. E. Adrian, G. R. Greenberg, M. L. Fitzpatrick, S. R. Bloom

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Bovine pancreatic polypeptide (PP) was infused intravenously in 5 healthy subjects on two separate occasions with mean doses of 1 and 2 pmol kg^-1 min^-1, respectively, which achieved plasma levels equal to and twice those observed after a normal mixed breakfast. The gastric emptying of a carbohydrate-rich breakfast 20 min after the start of each PP infusion was not significantly different from a control infusion of 0.15 M saline. PP is unlikely to be an important physiological modulator of gastric emptying rate in man.

Original language	English
Pages (from-to)	214-218
Number of pages	5
Journal	Digestion
Volume	21
Issue number	4
DOIs	https://doi.org/10.1159/000198565
Publication status	Published - 1981
Externally published	Yes

ASJC Scopus subject areas

Gastroenterology

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abstract = "Bovine pancreatic polypeptide (PP) was infused intravenously in 5 healthy subjects on two separate occasions with mean doses of 1 and 2 pmol kg-1 min-1, respectively, which achieved plasma levels equal to and twice those observed after a normal mixed breakfast. The gastric emptying of a carbohydrate-rich breakfast 20 min after the start of each PP infusion was not significantly different from a control infusion of 0.15 M saline. PP is unlikely to be an important physiological modulator of gastric emptying rate in man.",

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AU - Adrian, T. E.

AU - Greenberg, G. R.

AU - Fitzpatrick, M. L.

AU - Bloom, S. R.

PY - 1981

Y1 - 1981

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AB - Bovine pancreatic polypeptide (PP) was infused intravenously in 5 healthy subjects on two separate occasions with mean doses of 1 and 2 pmol kg-1 min-1, respectively, which achieved plasma levels equal to and twice those observed after a normal mixed breakfast. The gastric emptying of a carbohydrate-rich breakfast 20 min after the start of each PP infusion was not significantly different from a control infusion of 0.15 M saline. PP is unlikely to be an important physiological modulator of gastric emptying rate in man.

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Lack of effect of pancreatic polypeptide in the rate of gastric emptying and gut hormone release during breakfast

Abstract

ASJC Scopus subject areas

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