Lack of effect of pancreatic polypeptide in the rate of gastric emptying and gut hormone release during breakfast

T. E. Adrian; G. R. Greenberg; M. L. Fitzpatrick; S. R. Bloom

doi:10.1159/000198565

Lack of effect of pancreatic polypeptide in the rate of gastric emptying and gut hormone release during breakfast

T. E. Adrian
, G. R. Greenberg
, M. L. Fitzpatrick
, S. R. Bloom

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Bovine pancreatic polypeptide (PP) was infused intravenously in 5 healthy subjects on two separate occasions with mean doses of 1 and 2 pmol kg^-1 min^-1, respectively, which achieved plasma levels equal to and twice those observed after a normal mixed breakfast. The gastric emptying of a carbohydrate-rich breakfast 20 min after the start of each PP infusion was not significantly different from a control infusion of 0.15 M saline. PP is unlikely to be an important physiological modulator of gastric emptying rate in man.

Original language	English
Pages (from-to)	214-218
Number of pages	5
Journal	Digestion
Volume	21
Issue number	4
DOIs	https://doi.org/10.1159/000198565
Publication status	Published - 1981
Externally published	Yes

ASJC Scopus subject areas

Gastroenterology

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abstract = "Bovine pancreatic polypeptide (PP) was infused intravenously in 5 healthy subjects on two separate occasions with mean doses of 1 and 2 pmol kg-1 min-1, respectively, which achieved plasma levels equal to and twice those observed after a normal mixed breakfast. The gastric emptying of a carbohydrate-rich breakfast 20 min after the start of each PP infusion was not significantly different from a control infusion of 0.15 M saline. PP is unlikely to be an important physiological modulator of gastric emptying rate in man.",

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AU - Adrian, T. E.

AU - Greenberg, G. R.

AU - Fitzpatrick, M. L.

AU - Bloom, S. R.

PY - 1981

Y1 - 1981

N2 - Bovine pancreatic polypeptide (PP) was infused intravenously in 5 healthy subjects on two separate occasions with mean doses of 1 and 2 pmol kg-1 min-1, respectively, which achieved plasma levels equal to and twice those observed after a normal mixed breakfast. The gastric emptying of a carbohydrate-rich breakfast 20 min after the start of each PP infusion was not significantly different from a control infusion of 0.15 M saline. PP is unlikely to be an important physiological modulator of gastric emptying rate in man.

AB - Bovine pancreatic polypeptide (PP) was infused intravenously in 5 healthy subjects on two separate occasions with mean doses of 1 and 2 pmol kg-1 min-1, respectively, which achieved plasma levels equal to and twice those observed after a normal mixed breakfast. The gastric emptying of a carbohydrate-rich breakfast 20 min after the start of each PP infusion was not significantly different from a control infusion of 0.15 M saline. PP is unlikely to be an important physiological modulator of gastric emptying rate in man.

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U2 - 10.1159/000198565

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JO - Digestion

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ER -

Lack of effect of pancreatic polypeptide in the rate of gastric emptying and gut hormone release during breakfast

Abstract

ASJC Scopus subject areas

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