@inproceedings{681e1cbc1ab541748402ab8e05e45e0b,
title = "Large scale serial two-photon microscopy to investigate local vascular changes in whole rodent brain models of Alzheimer's disease",
abstract = "In this study, an automated serial two-photon microscope was used to image a fluorescent gelatin filled rodent's brain in 3D. A method to compute vascular density using automatic segmentation was combined with coregistration techniques to build group-level vasculature metrics. By studying the medial prefrontal cortex and the hippocampal formation of 3 age groups (2, 4.5 and 8 months old), we compared vascular density for both WT and an Alzheimer model transgenic brain (APP/PS1). We observe a loss of vascular density caused by the ageing process and we propose further analysis to confirm our results.",
keywords = "Alzheimer's disease, Serial imaging, Two-photon microscopy",
author = "P. Delafontaine-Martel and J. Lefebvre and R. Damseh and A. Castonguay and P. Tardif and F. Lesage",
note = "Publisher Copyright: {\textcopyright} 2018 SPIE.; Multiphoton Microscopy in the Biomedical Sciences XVIII 2018 ; Conference date: 28-01-2018 Through 30-01-2018",
year = "2018",
doi = "10.1117/12.2290060",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Ammasi Periasamy and Xie, {Xiaoliang S.} and Xie, {Xiaoliang S.} and Karsten Konig and So, {Peter T. C.}",
booktitle = "Multiphoton Microscopy in the Biomedical Sciences XVIII",
}