Levels of metabolic markers in drug-naive prediabetic and type 2 diabetic patients

Amal Akour, Violet Kasabri, Nailya Boulatova, Yasser Bustanji, Randa Naffa, Dana Hyasat, Nahla Khawaja, Haidar Bustanji, Ayman Zayed, Munther Momani

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Aims: Type 2 diabetes mellitus (T2DM) and prediabetes (pre-DM) are associated with changes in levels of metabolic markers. The main aim of this study is to compare the levels of omentin, irisin, endothelin-1, nesfatin, hepatocyte growth factor (HGF), fibroblast growth factor, and oxytocin (OXT) between normoglycemic and pre-DM/T2DM obese Jordanian patients. Methods: One hundred and ninety-eight adult Jordanian subjects were recruited. Demographic data and clinical parameters were collected. The serum levels of biomarkers were measured by enzymatic assay procedure. Results: Compared to normoglycemic (95 subjects), pre-DM/T2DM (103 subjects) displayed higher HGF (ng/ml) = 78.8 (71.4–104) versus 55.9 (45.3–66.6), p < 0.0001; and nesfatin (ng/ml) = 0.5 (0.4–0.7) versus 0.2 (0.1–0.4), p < 0.0001; betatrophin (ng/ml) = 1.2 (0.8–1.6) versus 0.22 (0.15–0.41), p < 0.0001. On the other hand, they had lower levels of omentin (ng/ml) = 2.1 (0.9–3.3) versus 3.6 (2.0–6.4), p < 0.0001, irisin (ng/ml) = 113.7 (88.9–142.9) versus 132.6 (110.7–147.8), p < 0.0001; and oxytocin (pg/ml) = 1077.9 (667.3–1506.0) versus 2180.1 (1464.5–2795.6), p < 0.0001; respectively. In comparison, FGF-21 (ng/ml) = 0.3 (0.2–0.5) versus 0.2 (0.1–0.4), and endothelin (pg/ml) = 2.7 (1.3–5.2) versus 2.8 (1.6–5.6) did not differ between the two groups (p > 0.05). Conclusions: In the present study, patients with pre-DM and T2DM have higher serum levels of metabolic HGF, nesfatin, and betatrophin and lower levels of omentin, irisin, and OXT. Future longitudinal and interventional studies are required to confirm the utility of these markers as novel progression or therapeutic targets in the pharmacotherapy of diabetes.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalActa Diabetologica
Volume54
Issue number2
DOIs
Publication statusPublished - Feb 1 2017
Externally publishedYes

Keywords

  • Oxytocin
  • Prediabetes
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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