Lexipafant and acute pancreatitis: A critical appraisal of the clinical trials

Fikri M. Abu-Zidan, John A. Windsor

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)


The recent clinical trials of lexipafant in the treatment of acute pancreatitis were undertaken with considerable optimism. It was expected that this single agent anticytokine would reduce the morbidity and mortality of this disease. Published clinical trials of lexipafant (BB-882) in acute pancreatitis were retrieved by MEDLINE, EM Base, and Science Citation Index. The critical appraisal included the question asked, design of the study, group and selection of patients, results, and statistical analysis. The historical sequence of the trials and the impact of commerce on their performance were highlighted. Lexipafant did not reduce mortality in severe acute pancreatitis. Comparison between the trials is difficult because of changes in study groups and dose. The clinical trials were designed without the benefit of open discussion of the preliminary pharmacological studies. The results of the trials have not been communicated in an open, timely, and systematic manner, probably because of commercial constraints.

Original languageEnglish
Pages (from-to)215-219
Number of pages5
JournalEuropean Journal of Surgery
Issue number4
Publication statusPublished - 2002


  • Acute pancreatitis
  • BB-882
  • Lexipafant
  • Platelet-activating factor antagonist

ASJC Scopus subject areas

  • Surgery


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