Life threatening diarrhoea ultimately cured by surgery

Urban Sjöqvist; Johan Permert; Robert Löfberg; Jörgen Larsson; Virgil Gadaleanu; Thomas E. Adrian

doi:10.1097/00042737-199811000-00011

Life threatening diarrhoea ultimately cured by surgery

Urban Sjöqvist, Johan Permert, Robert Löfberg, Jörgen Larsson, Virgil Gadaleanu, Thomas E. Adrian

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A 30-year-old previously healthy woman was diagnosed as having a vasoactive intestinal polypeptide (VIP)-producing tumour of the pancreas. Her medical history was typical for neuroendocrine gastrointestinal tumours, presenting initially with non-specific symptoms but eventually she developed life-threatening manifestations requiring intensive care due to severe dehydration. She immediately recovered following surgical resection. The patient had elevated serum concentrations of VIP as well as pancreastatin, and post-operatively elevated concentrations of three growth factors, IGF-I, EGF and TGF-α, were seen. The importance of the alterations in plasma concentrations of the different peptides for her symptomatology are discussed.

Original language	English
Pages (from-to)	963-967
Number of pages	5
Journal	European Journal of Gastroenterology and Hepatology
Volume	10
Issue number	11
DOIs	https://doi.org/10.1097/00042737-199811000-00011
Publication status	Published - 1998
Externally published	Yes

Keywords

Diarrhoea
Endocrine tumour of the pancreas
Gastrointestinal growth factors
Gastrointestinal hormones
Octreotide
Vasoactive intestinal polypeptide

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1097/00042737-199811000-00011

Cite this

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title = "Life threatening diarrhoea ultimately cured by surgery",

abstract = "A 30-year-old previously healthy woman was diagnosed as having a vasoactive intestinal polypeptide (VIP)-producing tumour of the pancreas. Her medical history was typical for neuroendocrine gastrointestinal tumours, presenting initially with non-specific symptoms but eventually she developed life-threatening manifestations requiring intensive care due to severe dehydration. She immediately recovered following surgical resection. The patient had elevated serum concentrations of VIP as well as pancreastatin, and post-operatively elevated concentrations of three growth factors, IGF-I, EGF and TGF-α, were seen. The importance of the alterations in plasma concentrations of the different peptides for her symptomatology are discussed.",

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pages = "963--967",

journal = "European Journal of Gastroenterology and Hepatology",

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T1 - Life threatening diarrhoea ultimately cured by surgery

AU - Sjöqvist, Urban

AU - Permert, Johan

AU - Löfberg, Robert

AU - Larsson, Jörgen

AU - Gadaleanu, Virgil

AU - Adrian, Thomas E.

PY - 1998

Y1 - 1998

N2 - A 30-year-old previously healthy woman was diagnosed as having a vasoactive intestinal polypeptide (VIP)-producing tumour of the pancreas. Her medical history was typical for neuroendocrine gastrointestinal tumours, presenting initially with non-specific symptoms but eventually she developed life-threatening manifestations requiring intensive care due to severe dehydration. She immediately recovered following surgical resection. The patient had elevated serum concentrations of VIP as well as pancreastatin, and post-operatively elevated concentrations of three growth factors, IGF-I, EGF and TGF-α, were seen. The importance of the alterations in plasma concentrations of the different peptides for her symptomatology are discussed.

AB - A 30-year-old previously healthy woman was diagnosed as having a vasoactive intestinal polypeptide (VIP)-producing tumour of the pancreas. Her medical history was typical for neuroendocrine gastrointestinal tumours, presenting initially with non-specific symptoms but eventually she developed life-threatening manifestations requiring intensive care due to severe dehydration. She immediately recovered following surgical resection. The patient had elevated serum concentrations of VIP as well as pancreastatin, and post-operatively elevated concentrations of three growth factors, IGF-I, EGF and TGF-α, were seen. The importance of the alterations in plasma concentrations of the different peptides for her symptomatology are discussed.

KW - Diarrhoea

KW - Endocrine tumour of the pancreas

KW - Gastrointestinal growth factors

KW - Gastrointestinal hormones

KW - Octreotide

KW - Vasoactive intestinal polypeptide

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JO - European Journal of Gastroenterology and Hepatology

JF - European Journal of Gastroenterology and Hepatology

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ER -

Life threatening diarrhoea ultimately cured by surgery

Abstract

Keywords

ASJC Scopus subject areas

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