Life threatening diarrhoea ultimately cured by surgery

Urban Sjöqvist, Johan Permert, Robert Löfberg, Jörgen Larsson, Virgil Gadaleanu, Thomas E. Adrian

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


A 30-year-old previously healthy woman was diagnosed as having a vasoactive intestinal polypeptide (VIP)-producing tumour of the pancreas. Her medical history was typical for neuroendocrine gastrointestinal tumours, presenting initially with non-specific symptoms but eventually she developed life-threatening manifestations requiring intensive care due to severe dehydration. She immediately recovered following surgical resection. The patient had elevated serum concentrations of VIP as well as pancreastatin, and post-operatively elevated concentrations of three growth factors, IGF-I, EGF and TGF-α, were seen. The importance of the alterations in plasma concentrations of the different peptides for her symptomatology are discussed.

Original languageEnglish
Pages (from-to)963-967
Number of pages5
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number11
Publication statusPublished - 1998
Externally publishedYes


  • Diarrhoea
  • Endocrine tumour of the pancreas
  • Gastrointestinal growth factors
  • Gastrointestinal hormones
  • Octreotide
  • Vasoactive intestinal polypeptide

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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