Abstract
The effect of long-term treatment of chloroquine (CAS 54-05-7) (20 mg/kg body weight) on serum lipid components and its relation to the retinotoxic effect was studied in albino rats. Chloroquine was found to form lamellar lysosome-like structures within the photoreceptor layer, as well as the pigment epithelium and neuroretinal layers. Biochemically, hypolipidemia in the serum was observed mainly due to the decrease in phospholipid portion. It was hypothesized that due to the inhibition of the degradation process in the defective lysosomes, the retinal cells were denied the re-use of their own phospholipids, and thereby resort to their uptake from the serum.
| Original language | English |
|---|---|
| Pages (from-to) | 1231-1235 |
| Number of pages | 5 |
| Journal | Arzneimittel-Forschung/Drug Research |
| Volume | 45 |
| Issue number | 11 |
| Publication status | Published - 1995 |
| Externally published | Yes |
Keywords
- CAS 54-05-7
- chloroquine, lipidemic effect, retinotoxicity
ASJC Scopus subject areas
- Drug Discovery