Lipophilicity determination of some ACE inhibitors by TLC

Tamás Csermely, Huba Kalász, Katalin Deák, Mohammed Y. Hasan, Ferenc Darvas, Georg Petroianu

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


A simple and reliable reversed-phase TLC method was used to determine the lipophilicity of ACE inhibitors. The TLC silica plates were saturated with paraffin using continuous development with 10% paraffin in hexane for 18 hours. The TLC silica particles covered with the paraffin are used as an inexpensive substituent of the usual RP-18 TLC stationary phase.

Original languageEnglish
Pages (from-to)2019-2034
Number of pages16
JournalJournal of Liquid Chromatography and Related Technologies
Issue number13
Publication statusPublished - Jan 2008


  • ACE inhibitors
  • Lipophilicity calculation
  • Lipophilicity determi-nation
  • Reversed-phase TLC

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Pharmaceutical Science
  • Clinical Biochemistry


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