Lipophilicity determination of some ACE inhibitors by TLC

Tamás Csermely; Huba Kalász; Katalin Deák; Mohammed Y. Hasan; Ferenc Darvas; Georg Petroianu

doi:10.1080/10826070802198410

Lipophilicity determination of some ACE inhibitors by TLC

Tamás Csermely
, Huba Kalász
, Katalin Deák
, Mohammed Y. Hasan
, Ferenc Darvas
, Georg Petroianu

Department of Pharmacology and Therapeutics

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

A simple and reliable reversed-phase TLC method was used to determine the lipophilicity of ACE inhibitors. The TLC silica plates were saturated with paraffin using continuous development with 10% paraffin in hexane for 18 hours. The TLC silica particles covered with the paraffin are used as an inexpensive substituent of the usual RP-18 TLC stationary phase.

Original language	English
Pages (from-to)	2019-2034
Number of pages	16
Journal	Journal of Liquid Chromatography and Related Technologies
Volume	31
Issue number	13
DOIs	https://doi.org/10.1080/10826070802198410
Publication status	Published - Jan 2008

Keywords

ACE inhibitors
Lipophilicity calculation
Lipophilicity determi-nation
Reversed-phase TLC

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Pharmaceutical Science
Clinical Biochemistry

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10.1080/10826070802198410

Cite this

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title = "Lipophilicity determination of some ACE inhibitors by TLC",

abstract = "A simple and reliable reversed-phase TLC method was used to determine the lipophilicity of ACE inhibitors. The TLC silica plates were saturated with paraffin using continuous development with 10\% paraffin in hexane for 18 hours. The TLC silica particles covered with the paraffin are used as an inexpensive substituent of the usual RP-18 TLC stationary phase.",

keywords = "ACE inhibitors, Lipophilicity calculation, Lipophilicity determi-nation, Reversed-phase TLC",

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note = "Funding Information: Thanks are due to Profs. Dr. K. Tekes and Dr. K. Tak{\'a}cs-Nov{\'a}k for their valuable advices. Financial support from grant of T049492 of OTKA (Hungarian National Grant Foundation) is appreciated.",

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AU - Kalász, Huba

AU - Deák, Katalin

AU - Hasan, Mohammed Y.

AU - Darvas, Ferenc

AU - Petroianu, Georg

N1 - Funding Information: Thanks are due to Profs. Dr. K. Tekes and Dr. K. Takács-Novák for their valuable advices. Financial support from grant of T049492 of OTKA (Hungarian National Grant Foundation) is appreciated.

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KW - Lipophilicity calculation

KW - Lipophilicity determi-nation

KW - Reversed-phase TLC

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Lipophilicity determination of some ACE inhibitors by TLC

Abstract

Keywords

ASJC Scopus subject areas

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