TY - JOUR
T1 - Liposome
T2 - composition, characterisation, preparation, and recent innovation in clinical applications
AU - Ahmed, Kamel S.
AU - Hussein, Saied A.
AU - Ali, Abdelmoneim H.
AU - Korma, Sameh A.
AU - Lipeng, Qiu
AU - Jinghua, Chen
N1 - Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2019/8/9
Y1 - 2019/8/9
N2 - In the last decades, pharmaceutical interested researches aimed to develop novel and innovative drug delivery techniques in the medical and pharmaceutical fields. Recently, phospholipid vesicles (Liposomes) are the most known versatile assemblies in the drug delivery systems. The discovery of liposomes arises from self-forming enclosed phospholipid bilayer upon coming in contact with the aqueous solution. Liposomes are uni or multilamellar vesicles consisting of phospholipids produced naturally or synthetically, which are readily non-toxic, biodegradable, and are readily produced on a large scale. Various phospholipids, for instance, soybean, egg yolk, synthetic, and hydrogenated phosphatidylcholine consider the most popular types used in different kinds of formulations. This review summarises liposomes composition, characterisation, methods of preparation, and their applications in different medical fields including cancer therapy, vaccine, ocular delivery, wound healing, and some dermatological applications.
AB - In the last decades, pharmaceutical interested researches aimed to develop novel and innovative drug delivery techniques in the medical and pharmaceutical fields. Recently, phospholipid vesicles (Liposomes) are the most known versatile assemblies in the drug delivery systems. The discovery of liposomes arises from self-forming enclosed phospholipid bilayer upon coming in contact with the aqueous solution. Liposomes are uni or multilamellar vesicles consisting of phospholipids produced naturally or synthetically, which are readily non-toxic, biodegradable, and are readily produced on a large scale. Various phospholipids, for instance, soybean, egg yolk, synthetic, and hydrogenated phosphatidylcholine consider the most popular types used in different kinds of formulations. This review summarises liposomes composition, characterisation, methods of preparation, and their applications in different medical fields including cancer therapy, vaccine, ocular delivery, wound healing, and some dermatological applications.
KW - Liposomes
KW - applications
KW - cancer
KW - drug delivery
KW - phospholipids
KW - wound healing
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U2 - 10.1080/1061186X.2018.1527337
DO - 10.1080/1061186X.2018.1527337
M3 - Review article
C2 - 30239255
AN - SCOPUS:85055092909
SN - 1061-186X
VL - 27
SP - 742
EP - 761
JO - Journal of Drug Targeting
JF - Journal of Drug Targeting
IS - 7
ER -
