Lipoxygenase and cyclooxygenase metabolism: New insights in treatment and chemoprevention of pancreatic cancer

Xian Zhong Ding; Rene Hennig; Thomas E. Adrian

doi:10.1186/1476-4598-2-10

Lipoxygenase and cyclooxygenase metabolism: New insights in treatment and chemoprevention of pancreatic cancer

Xian Zhong Ding, Rene Hennig, Thomas E. Adrian

Research output: Contribution to journal › Review article › peer-review

127 Citations (Scopus)

Abstract

The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of both cyclooxygenases and lipoxygenases have been reported in pancreatic cancer. In this article, we aim to provide a brief summary of (1) our understanding of the roles of these enzymes in pancreatic cancer tumorigenesis and progression; and (2) the potential of using cyclooxygenase and lipoxygenase inhibitors for pancreatic cancer treatment and prevention.

Original language	English
Article number	10
Journal	Molecular Cancer
Volume	2
DOIs	https://doi.org/10.1186/1476-4598-2-10
Publication status	Published - Jan 7 2003
Externally published	Yes

Keywords

Cyclooxygenase
Lipoxygenase
Pancreatic cancer

ASJC Scopus subject areas

Molecular Medicine
Oncology
Cancer Research

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10.1186/1476-4598-2-10

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abstract = "The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of both cyclooxygenases and lipoxygenases have been reported in pancreatic cancer. In this article, we aim to provide a brief summary of (1) our understanding of the roles of these enzymes in pancreatic cancer tumorigenesis and progression; and (2) the potential of using cyclooxygenase and lipoxygenase inhibitors for pancreatic cancer treatment and prevention.",

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T2 - New insights in treatment and chemoprevention of pancreatic cancer

AU - Ding, Xian Zhong

AU - Hennig, Rene

AU - Adrian, Thomas E.

PY - 2003/1/7

Y1 - 2003/1/7

N2 - The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of both cyclooxygenases and lipoxygenases have been reported in pancreatic cancer. In this article, we aim to provide a brief summary of (1) our understanding of the roles of these enzymes in pancreatic cancer tumorigenesis and progression; and (2) the potential of using cyclooxygenase and lipoxygenase inhibitors for pancreatic cancer treatment and prevention.

AB - The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of both cyclooxygenases and lipoxygenases have been reported in pancreatic cancer. In this article, we aim to provide a brief summary of (1) our understanding of the roles of these enzymes in pancreatic cancer tumorigenesis and progression; and (2) the potential of using cyclooxygenase and lipoxygenase inhibitors for pancreatic cancer treatment and prevention.

KW - Cyclooxygenase

KW - Lipoxygenase

KW - Pancreatic cancer

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JO - Molecular Cancer

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ER -

Lipoxygenase and cyclooxygenase metabolism: New insights in treatment and chemoprevention of pancreatic cancer

Abstract

Keywords

ASJC Scopus subject areas

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