Lipoxygenase and cyclooxygenase metabolism: New insights in treatment and chemoprevention of pancreatic cancer

Xian Zhong Ding, Rene Hennig, Thomas E. Adrian

Research output: Contribution to journalReview articlepeer-review

131 Citations (Scopus)

Abstract

The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of both cyclooxygenases and lipoxygenases have been reported in pancreatic cancer. In this article, we aim to provide a brief summary of (1) our understanding of the roles of these enzymes in pancreatic cancer tumorigenesis and progression; and (2) the potential of using cyclooxygenase and lipoxygenase inhibitors for pancreatic cancer treatment and prevention.

Original languageEnglish
Article number10
JournalMolecular Cancer
Volume2
DOIs
Publication statusPublished - Jan 7 2003
Externally publishedYes

Keywords

  • Cyclooxygenase
  • Lipoxygenase
  • Pancreatic cancer

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research

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