Long-term adrenalectomy decreases NMDA receptors in rat hippocampus

H. S. Mangat; A. Islam; C. Heigensköld; A. Mustafa; B. Winblad; A. Adem

doi:10.1097/00001756-199806220-00018

Long-term adrenalectomy decreases NMDA receptors in rat hippocampus

H. S. Mangat, A. Islam, C. Heigensköld, A. Mustafa, B. Winblad, A. Adem

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The effect of long-term adrenalectomy on NMDA receptors in the rat hippocampus was studied. Hippocampal sections of control and adrenalectomized rats were incubated with [³H]MK-801, a radiolabeled non-competitive inhibitor of the NMDA receptor. Analysis by in vitro autoradiography showed a significant decrease in [³H]MK-801 binding in the dentate gyrus, CA1 and CA4 areas, as well as the temporal cortex. Results of this study suggest that glucocorticoids are vital for the regulation of the NMDA receptors.

Original language	English
Pages (from-to)	2011-2014
Number of pages	4
Journal	NeuroReport
Volume	9
Issue number	9
DOIs	https://doi.org/10.1097/00001756-199806220-00018
Publication status	Published - Jun 22 1998
Externally published	Yes

Keywords

Adrenalectomy
Glucocorticoids
Hippocampus
NMDA receptors
Neurodegeneration

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-199806220-00018

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abstract = "The effect of long-term adrenalectomy on NMDA receptors in the rat hippocampus was studied. Hippocampal sections of control and adrenalectomized rats were incubated with [3H]MK-801, a radiolabeled non-competitive inhibitor of the NMDA receptor. Analysis by in vitro autoradiography showed a significant decrease in [3H]MK-801 binding in the dentate gyrus, CA1 and CA4 areas, as well as the temporal cortex. Results of this study suggest that glucocorticoids are vital for the regulation of the NMDA receptors.",

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AU - Mangat, H. S.

AU - Islam, A.

AU - Heigensköld, C.

AU - Mustafa, A.

AU - Winblad, B.

AU - Adem, A.

PY - 1998/6/22

Y1 - 1998/6/22

N2 - The effect of long-term adrenalectomy on NMDA receptors in the rat hippocampus was studied. Hippocampal sections of control and adrenalectomized rats were incubated with [3H]MK-801, a radiolabeled non-competitive inhibitor of the NMDA receptor. Analysis by in vitro autoradiography showed a significant decrease in [3H]MK-801 binding in the dentate gyrus, CA1 and CA4 areas, as well as the temporal cortex. Results of this study suggest that glucocorticoids are vital for the regulation of the NMDA receptors.

AB - The effect of long-term adrenalectomy on NMDA receptors in the rat hippocampus was studied. Hippocampal sections of control and adrenalectomized rats were incubated with [3H]MK-801, a radiolabeled non-competitive inhibitor of the NMDA receptor. Analysis by in vitro autoradiography showed a significant decrease in [3H]MK-801 binding in the dentate gyrus, CA1 and CA4 areas, as well as the temporal cortex. Results of this study suggest that glucocorticoids are vital for the regulation of the NMDA receptors.

KW - Adrenalectomy

KW - Glucocorticoids

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KW - NMDA receptors

KW - Neurodegeneration

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Long-term adrenalectomy decreases NMDA receptors in rat hippocampus

Abstract

Keywords

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