Abstract
The effect of long-term adrenalectomy on NMDA receptors in the rat hippocampus was studied. Hippocampal sections of control and adrenalectomized rats were incubated with [3H]MK-801, a radiolabeled non-competitive inhibitor of the NMDA receptor. Analysis by in vitro autoradiography showed a significant decrease in [3H]MK-801 binding in the dentate gyrus, CA1 and CA4 areas, as well as the temporal cortex. Results of this study suggest that glucocorticoids are vital for the regulation of the NMDA receptors.
Original language | English |
---|---|
Pages (from-to) | 2011-2014 |
Number of pages | 4 |
Journal | NeuroReport |
Volume | 9 |
Issue number | 9 |
DOIs | |
Publication status | Published - Jun 22 1998 |
Externally published | Yes |
Keywords
- Adrenalectomy
- Glucocorticoids
- Hippocampus
- NMDA receptors
- Neurodegeneration
ASJC Scopus subject areas
- Neuroscience(all)