Long-term adrenalectomy decreases NMDA receptors in rat hippocampus

H. S. Mangat, A. Islam, C. Heigensköld, A. Mustafa, B. Winblad, A. Adem

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The effect of long-term adrenalectomy on NMDA receptors in the rat hippocampus was studied. Hippocampal sections of control and adrenalectomized rats were incubated with [3H]MK-801, a radiolabeled non-competitive inhibitor of the NMDA receptor. Analysis by in vitro autoradiography showed a significant decrease in [3H]MK-801 binding in the dentate gyrus, CA1 and CA4 areas, as well as the temporal cortex. Results of this study suggest that glucocorticoids are vital for the regulation of the NMDA receptors.

Original languageEnglish
Pages (from-to)2011-2014
Number of pages4
Issue number9
Publication statusPublished - Jun 22 1998
Externally publishedYes


  • Adrenalectomy
  • Glucocorticoids
  • Hippocampus
  • NMDA receptors
  • Neurodegeneration

ASJC Scopus subject areas

  • General Neuroscience


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