Long-term effect of prefrontal lobotomy on verbal fluency in patients with schizophrenia

Emmanuel Stip, Marie Josée Bigras, Adham Mancini-Marïe, Marie Ève Cosset, Deborah Black, André Roch Lecours

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Objective. This study investigated the long-term effects of bilateral prefrontal leukotomy on lexical abilities in schizophrenia subjects. Method. we compared performances of leukotomized (LSP), non-leukotomized schizophrenia patients (NLSP) and normal controls, using a test of verbal fluency. Multiple case and triple comparison design were implemented. i.e., the performance of each LSP was compared to that of NLSP and that of a normal control. The sample consisted of four LSP, four NLSP, and four normal subjects. Subjects were matched in sex, age, handedness, and schooling. In Addition, schizophrenia groups were matched in diagnosis and years of hospitalization. Quantitative and qualitative analyses of generated words and errors produced by subjects were carried out. Results. A deficiency in both groups of schizophrenia was observed, although a better performance in LSP patients was detected. Conclusion. Intact Lexical ability in LSP indicates its poor relation to the frontal lobe.

Original languageEnglish
Pages (from-to)466-469
Number of pages4
JournalBrain and Cognition
Issue number3
Publication statusPublished - Aug 2004
Externally publishedYes


  • Leukotomy
  • Lexical ability
  • Schizophrenia
  • Verbal fluency

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience


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