Loss of neurones after long-term adrenalectomy in the adult rat hippocampal formation

Abdu Adem; Atiqul Islam; Nenad Bogdanovic; Kjell Carlstrom; Bengt Winblad

doi:10.1097/00001756-199411000-00020

Loss of neurones after long-term adrenalectomy in the adult rat hippocampal formation

Abdu Adem, Atiqul Islam, Nenad Bogdanovic, Kjell Carlstrom, Bengt Winblad

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The effects of long-term adrenalectomy (ADX) on hippocampal neurones were investigated 5 months after surgery in male Sprague-Dawley rats. Cells in Nissl-stained sections from ADX rats were counted and compared with those in sections from sham-operated rats. The ADX rats had a significantly reduced number of dentate granule cells. A novel finding was a significant reduction in the number of pyramidal cells in CA1, CA2, CA3 and CA4 regions of tne hippocampus. Thus long-term adrenalectomy causes loss of dentate granule cells and pyramidal neurones of the hippocampus.

Original language	English
Pages (from-to)	2285-2288
Number of pages	4
Journal	NeuroReport
Volume	5
Issue number	17
DOIs	https://doi.org/10.1097/00001756-199411000-00020
Publication status	Published - Nov 1994
Externally published	Yes

Keywords

Adrenalectomy
Dentate gyrus
Hippocampus
Neuronal degeneration
Pyramidal cells

ASJC Scopus subject areas

General Neuroscience

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10.1097/00001756-199411000-00020

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abstract = "The effects of long-term adrenalectomy (ADX) on hippocampal neurones were investigated 5 months after surgery in male Sprague-Dawley rats. Cells in Nissl-stained sections from ADX rats were counted and compared with those in sections from sham-operated rats. The ADX rats had a significantly reduced number of dentate granule cells. A novel finding was a significant reduction in the number of pyramidal cells in CA1, CA2, CA3 and CA4 regions of tne hippocampus. Thus long-term adrenalectomy causes loss of dentate granule cells and pyramidal neurones of the hippocampus.",

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AU - Adem, Abdu

AU - Islam, Atiqul

AU - Bogdanovic, Nenad

AU - Carlstrom, Kjell

AU - Winblad, Bengt

PY - 1994/11

Y1 - 1994/11

N2 - The effects of long-term adrenalectomy (ADX) on hippocampal neurones were investigated 5 months after surgery in male Sprague-Dawley rats. Cells in Nissl-stained sections from ADX rats were counted and compared with those in sections from sham-operated rats. The ADX rats had a significantly reduced number of dentate granule cells. A novel finding was a significant reduction in the number of pyramidal cells in CA1, CA2, CA3 and CA4 regions of tne hippocampus. Thus long-term adrenalectomy causes loss of dentate granule cells and pyramidal neurones of the hippocampus.

AB - The effects of long-term adrenalectomy (ADX) on hippocampal neurones were investigated 5 months after surgery in male Sprague-Dawley rats. Cells in Nissl-stained sections from ADX rats were counted and compared with those in sections from sham-operated rats. The ADX rats had a significantly reduced number of dentate granule cells. A novel finding was a significant reduction in the number of pyramidal cells in CA1, CA2, CA3 and CA4 regions of tne hippocampus. Thus long-term adrenalectomy causes loss of dentate granule cells and pyramidal neurones of the hippocampus.

KW - Adrenalectomy

KW - Dentate gyrus

KW - Hippocampus

KW - Neuronal degeneration

KW - Pyramidal cells

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Loss of neurones after long-term adrenalectomy in the adult rat hippocampal formation

Abstract

Keywords

ASJC Scopus subject areas

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