TY - JOUR
T1 - Lung deposition of particles by airway generation in healthy subjects
T2 - Three-dimensional radionuclide imaging and numerical model prediction
AU - Hashish, Adel H.
AU - Fleming, John S.
AU - Conway, Joy
AU - Halson, Peter
AU - Moore, Elizabeth
AU - Williams, Trevor J.
AU - Bailey, Adrian G.
AU - Nassim, Michael
AU - Holgate, Stephen T.
PY - 1998
Y1 - 1998
N2 - Multi-modality medical imaging enables measurement of the three-dimensional spatial distribution of inhaled, radiolabelled aerosol within the human lung. Using a conceptual model of spatial lung morphology, this data may be transformed to provide information on deposition by airway generation in the conducting airways. This methodology has been used to study intrapulmonary deposition patterns in control subjects for two polydisperse aerosols produced by jet-type nebulizers of mass median aerodynamic diameter (MMAD) 1.8 and 6.8 μm. Comparison between derived experimental results and those from computer modelling shows reasonable agreement for total body, oropharynx and lung deposition and also for the difference in deposition pattern between the two aerosols. However, experiment suggests significantly less deposition in the central airways than is predicted by modelling. The new methodology has considerable potential in the fields of inhalation therapy and deposition modelling though more detailed validation is still required.
AB - Multi-modality medical imaging enables measurement of the three-dimensional spatial distribution of inhaled, radiolabelled aerosol within the human lung. Using a conceptual model of spatial lung morphology, this data may be transformed to provide information on deposition by airway generation in the conducting airways. This methodology has been used to study intrapulmonary deposition patterns in control subjects for two polydisperse aerosols produced by jet-type nebulizers of mass median aerodynamic diameter (MMAD) 1.8 and 6.8 μm. Comparison between derived experimental results and those from computer modelling shows reasonable agreement for total body, oropharynx and lung deposition and also for the difference in deposition pattern between the two aerosols. However, experiment suggests significantly less deposition in the central airways than is predicted by modelling. The new methodology has considerable potential in the fields of inhalation therapy and deposition modelling though more detailed validation is still required.
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U2 - 10.1016/S0021-8502(97)00023-2
DO - 10.1016/S0021-8502(97)00023-2
M3 - Article
AN - SCOPUS:0031985979
SN - 0021-8502
VL - 29
SP - 205
EP - 215
JO - Journal of Aerosol Science
JF - Journal of Aerosol Science
IS - 1-2
ER -