TY - JOUR
T1 - Lung toxicities of core-shell nanoparticles composed of carbon, cobalt, and silica
AU - Al Samri, Mohammed T.
AU - Silva, Rafael
AU - Almarzooqi, Saeeda
AU - Albawardi, Alia
AU - Othman, Aws Rashad Diab
AU - Al Hanjeri, Ruqayya S.M.S.
AU - Al Dawaar, Shaikha K.M.
AU - Tariq, Saeed
AU - Souid, Abdul Kader
AU - Asefa, Tewodros
PY - 2013/3/20
Y1 - 2013/3/20
N2 - We present here comparative assessments of murine lung toxicity (biocompatibility) after in vitro and in vivo exposures to carbon (C-SiO2-etched), carbon-silica (C-SiO2), carbon-cobalt-silica (C-Co-SiO2), and carbon-cobalt oxide-silica (C-Co3O4-SiO2) nanoparticles. These nanoparticles have potential applications in clinical medicine and bioimaging, and thus their possible adverse events require thorough investigation. The primary aim of this work was to explore whether the nanoparticles are biocompatible with pneumatocyte bioenergetics (cellular respiration and adenosine triphosphate content). Other objectives included assessments of caspase activity, lung structure, and cellular organelles. Pneumatocyte bioenergetics of murine lung remained preserved after treatment with C-SiO2-etched or C-SiO2 nanoparticles. C-SiO2-etched nanoparticles, however, increased caspase activity and altered lung structure more than C-SiO2 did. Consistent with the known mitochondrial toxicity of cobalt, both C-Co-SiO2 and C-Co3O4-SiO2 impaired lung tissue bioenergetics. C-Co-SiO2, however, increased caspase activity and altered lung structure more than C-Co3O4-SiO2. The results indicate that silica shell is essential for biocompatibility. Furthermore, cobalt oxide is the preferred phase over the zerovalent Co(0) phase to impart biocompatibility to cobalt-based nanoparticles.
AB - We present here comparative assessments of murine lung toxicity (biocompatibility) after in vitro and in vivo exposures to carbon (C-SiO2-etched), carbon-silica (C-SiO2), carbon-cobalt-silica (C-Co-SiO2), and carbon-cobalt oxide-silica (C-Co3O4-SiO2) nanoparticles. These nanoparticles have potential applications in clinical medicine and bioimaging, and thus their possible adverse events require thorough investigation. The primary aim of this work was to explore whether the nanoparticles are biocompatible with pneumatocyte bioenergetics (cellular respiration and adenosine triphosphate content). Other objectives included assessments of caspase activity, lung structure, and cellular organelles. Pneumatocyte bioenergetics of murine lung remained preserved after treatment with C-SiO2-etched or C-SiO2 nanoparticles. C-SiO2-etched nanoparticles, however, increased caspase activity and altered lung structure more than C-SiO2 did. Consistent with the known mitochondrial toxicity of cobalt, both C-Co-SiO2 and C-Co3O4-SiO2 impaired lung tissue bioenergetics. C-Co-SiO2, however, increased caspase activity and altered lung structure more than C-Co3O4-SiO2. The results indicate that silica shell is essential for biocompatibility. Furthermore, cobalt oxide is the preferred phase over the zerovalent Co(0) phase to impart biocompatibility to cobalt-based nanoparticles.
KW - Biocompatibility
KW - Carbon nanoparticles
KW - Cobalt nanoparticles
KW - Cobalt oxide nanoparticles
KW - Nanotoxicology
KW - Silica nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=84875552618&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875552618&partnerID=8YFLogxK
U2 - 10.2147/IJN.S39649
DO - 10.2147/IJN.S39649
M3 - Article
C2 - 23658487
AN - SCOPUS:84875552618
SN - 1176-9114
VL - 8
SP - 1223
EP - 1244
JO - International Journal of Nanomedicine
JF - International Journal of Nanomedicine
ER -