Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice

O. O. Ojo, D. K. Srinivasan, B. O. Owolabi, J. M. Conlon, P. R. Flatt, Y. H.A. Abdel-Wahab

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Background Magainin-AM2, a previously described amphibian host-defense peptide, stimulates insulin- and glucagon-like peptide-1-release in vitro. This study investigated anti-diabetic effects of the peptide in mice with diet-induced obesity and glucose intolerance.

Methods Male National Institute of Health Swiss mice were maintained on a high-fat diet for 12-weeks prior to the daily treatment with magainin-AM2. Various indices of glucose tolerance were monitored together with insulin secretory responsiveness of islets at conclusion of study.

Results Following twice daily treatment with magainin-AM2 for 15 days, no significant difference in body weight and food intake was observed compared with saline-treated high fat control animals. However, non-fasting blood glucose was significantly (P

Conclusion These results indicate that magainin-AM2 improves glucose tolerance, insulin sensitivity and islet beta cells secretory responsiveness in mice with obesity-diabetes. General significance The activity of magainin-AM2 suggests the possibility of exploiting this peptide for treatment of type 2 diabetes.

Original languageEnglish
Pages (from-to)80-87
Number of pages8
JournalBiochimica et Biophysica Acta - General Subjects
Issue number1
Publication statusPublished - Jan 2015
Externally publishedYes


  • Amphibian peptide
  • Magainin-AM2
  • Obesity Insulin-release
  • Type 2 diabetes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology


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