Malignant Diathesis from Jejunal‐Ileal Carcinoids

Karl A. Zucker, Walter E. Longo, Irvin M. Modlin, Anton J. Bilchik, Thomas E. Adrian

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


A facet of carcinoid tumors often not recognized is their close association with other, noncarcinoid malignancies. The clinical course of two patients with multiple ileal‐jejunal carcinoids and multiple other noncarcinoid malignancies is described. These patients were found to have elevated circulating levels of gastrin, bombesin, glucagon, enteroglucagon, pancreatic polypeptide, and peptide tyrosine tyrosine. These regulatory peptides have been demonstrated to promote trophic effects on the gastrointestinal tract as well as malignant tumors. We propose that the release of these bioactive hormones into the portal and systemic circulation by carcinoid tumors may play some role in their association with these multiple second tumors.

Original languageEnglish
Pages (from-to)182-186
Number of pages5
JournalThe American Journal of Gastroenterology
Issue number2
Publication statusPublished - Feb 1989
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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