Mammary carcinoma with osteoclast-like giant cells: A case report

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8 Citations (Scopus)


Mammary carcinoma with osteoclast-like giant cells is rare, and comprises less that 2% of breast carcinoma cases. Herein, we present a case of a 45-year-old woman who underwent breast lumpectomy and sentinel lymph node biopsy for a solitary well defined breast tumor. Histological examination revealed an invasive tumor composed of ducts, small nests and cribriform formations intermixed with a prominent osteoclast like giant cell component. The background stroma is hemorrhagic with conspicuous hemosiderin deposition. The paper will outline the clinico-pathologic characteristic features of this uncommon subtype as well as the current understanding on the pathogenesis of the osteoclast-like giant cells. The invasive carcinoma and the osteoclast-like giant cells staining patterns using immunohistochemical stains for estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, receptor activator of nuclear-kB, RANK ligand, and matrix metalloproteinase 1 are reported.

Original languageEnglish
Pages (from-to)9038-9043
Number of pages6
JournalInternational Journal of Clinical and Experimental Pathology
Issue number12
Publication statusPublished - 2014


  • Estrogen receptor (ER)
  • Human epidermal growth factor receptor 2 (Her2/neu)
  • Mammary carcinoma
  • Matrix metalloproteinase 1 (MMP1)
  • Osteoclast like giant cells
  • Progesterone receptor (PR)
  • RANK ligand (RANKL) expression
  • Receptor activator of nuclear-kB expression (RANK)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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