Management of peri-anal giant condyloma acuminatum - A case report and literature review

Farouk Safi, Omar Bekdache, Suhail Al-Salam, Mouied Alashari, Taha Mazen, Haytham El-Salhat

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Giant condyloma acuminatum (GCA), originally described by Buschke and Loewenstein in 1925 as a lesion of the penis, is more rarely seen in the anorectum and is characterized by clinical malignancy in the face of histologic benignity; however, malignant transformation to frankly invasive squamous-cell carcinoma has been described in about one-third of patients. In addition, malignant transformation has been reported in patients with 'ordinary' condylomata acuminata. Human papillomavirus, known to cause condylomata acuminata, is also known to induce these tumors and was found in 96% of 63 cases reviewed in the last 10 years. These lesions have a propensity for recurrence and a likelihood of malignant transformation, and lead to significant mortality. Therefore, early and radical R0 excision, along with vigilant follow-up, provides the hope for cure. Conservative and/or multimodal therapy has been reported in a few cases, but its effect is not yet proved. The authors report one case of GCA; in addition, they reviewed the literature over the last 10 years and compared with previous reviews.

Original languageEnglish
Pages (from-to)43-52
Number of pages10
JournalAsian Journal of Surgery
Issue number1
Publication statusPublished - Jan 2013


  • Buschke and Loewenstein tumor
  • development and therapy
  • diagnostic

ASJC Scopus subject areas

  • Surgery


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