Mapping the effect of drugs on ACE2 as a novel target site for COVID-19 therapy

H. F. Hetta; K. Muhammad; A. M. Algammal; H. Ramadan; M. S. Abdel-Rahman; M. Mabrok; G. Koneru; A. A. Elkady; G. El-Saber Batiha; Y. Waheed; N. Munawar; H. S.M. Farghaly

doi:10.26355/eurrev_202105_25963

Mapping the effect of drugs on ACE2 as a novel target site for COVID-19 therapy

H. F. Hetta, K. Muhammad, A. M. Algammal, H. Ramadan, M. S. Abdel-Rahman, M. Mabrok, G. Koneru, A. A. Elkady, G. El-Saber Batiha, Y. Waheed, N. Munawar, H. S.M. Farghaly

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Angiotensin converting enzyme 2 (ACE2) has potentially conflicting roles in health and disease. COVID-19 coronavirus binds to human cells via ACE2 receptor, which is expressed on almost all body organs. Boosting the ACE2 receptor levels on heart and lung cells may provide more cellular enter to virus thereby worsening the infection. Therefore, among the drug targets, ACE2 is suggested as a vital target of COVID-19 therapy. This hypothesis is based on the protective role of the drugs acting on ACE2. Therefore, this review discusses the impact and challenges of using ACE2 as a target in the current therapy of COVID-19.

Original language	English
Pages (from-to)	3923-3932
Number of pages	10
Journal	European review for medical and pharmacological sciences
Volume	25
Issue number	10
DOIs	https://doi.org/10.26355/eurrev_202105_25963
Publication status	Published - 2021

Keywords

Angiotensin converting enzyme 2 (ACE2)
Azithromycin
COVID-19
Hydroxychloroquine
Vitamin D
Zinc

ASJC Scopus subject areas

Pharmacology (medical)

Access to Document

10.26355/eurrev_202105_25963

Cite this

Hetta, H. F., Muhammad, K., Algammal, A. M., Ramadan, H., Abdel-Rahman, M. S., Mabrok, M., Koneru, G., Elkady, A. A., El-Saber Batiha, G., Waheed, Y., Munawar, N., & Farghaly, H. S. M. (2021). Mapping the effect of drugs on ACE2 as a novel target site for COVID-19 therapy. European review for medical and pharmacological sciences, 25(10), 3923-3932. https://doi.org/10.26355/eurrev_202105_25963

Hetta, HF, Muhammad, K, Algammal, AM, Ramadan, H, Abdel-Rahman, MS, Mabrok, M, Koneru, G, Elkady, AA, El-Saber Batiha, G, Waheed, Y, Munawar, N & Farghaly, HSM 2021, 'Mapping the effect of drugs on ACE2 as a novel target site for COVID-19 therapy', European review for medical and pharmacological sciences, vol. 25, no. 10, pp. 3923-3932. https://doi.org/10.26355/eurrev_202105_25963

@article{3dd20ebb85d64bb4bed5f888de6e9e9e,

title = "Mapping the effect of drugs on ACE2 as a novel target site for COVID-19 therapy",

abstract = "Angiotensin converting enzyme 2 (ACE2) has potentially conflicting roles in health and disease. COVID-19 coronavirus binds to human cells via ACE2 receptor, which is expressed on almost all body organs. Boosting the ACE2 receptor levels on heart and lung cells may provide more cellular enter to virus thereby worsening the infection. Therefore, among the drug targets, ACE2 is suggested as a vital target of COVID-19 therapy. This hypothesis is based on the protective role of the drugs acting on ACE2. Therefore, this review discusses the impact and challenges of using ACE2 as a target in the current therapy of COVID-19.",

keywords = "Angiotensin converting enzyme 2 (ACE2), Azithromycin, COVID-19, Hydroxychloroquine, Vitamin D, Zinc",

author = "Hetta, {H. F.} and K. Muhammad and Algammal, {A. M.} and H. Ramadan and Abdel-Rahman, {M. S.} and M. Mabrok and G. Koneru and Elkady, {A. A.} and {El-Saber Batiha}, G. and Y. Waheed and N. Munawar and Farghaly, {H. S.M.}",

year = "2021",

doi = "10.26355/eurrev_202105_25963",

language = "English",

volume = "25",

pages = "3923--3932",

journal = "European review for medical and pharmacological sciences",

issn = "1128-3602",

publisher = "Verduci Editore s.r.l",

number = "10",

}

TY - JOUR

T1 - Mapping the effect of drugs on ACE2 as a novel target site for COVID-19 therapy

AU - Hetta, H. F.

AU - Muhammad, K.

AU - Algammal, A. M.

AU - Ramadan, H.

AU - Abdel-Rahman, M. S.

AU - Mabrok, M.

AU - Koneru, G.

AU - Elkady, A. A.

AU - El-Saber Batiha, G.

AU - Waheed, Y.

AU - Munawar, N.

AU - Farghaly, H. S.M.

PY - 2021

Y1 - 2021

N2 - Angiotensin converting enzyme 2 (ACE2) has potentially conflicting roles in health and disease. COVID-19 coronavirus binds to human cells via ACE2 receptor, which is expressed on almost all body organs. Boosting the ACE2 receptor levels on heart and lung cells may provide more cellular enter to virus thereby worsening the infection. Therefore, among the drug targets, ACE2 is suggested as a vital target of COVID-19 therapy. This hypothesis is based on the protective role of the drugs acting on ACE2. Therefore, this review discusses the impact and challenges of using ACE2 as a target in the current therapy of COVID-19.

AB - Angiotensin converting enzyme 2 (ACE2) has potentially conflicting roles in health and disease. COVID-19 coronavirus binds to human cells via ACE2 receptor, which is expressed on almost all body organs. Boosting the ACE2 receptor levels on heart and lung cells may provide more cellular enter to virus thereby worsening the infection. Therefore, among the drug targets, ACE2 is suggested as a vital target of COVID-19 therapy. This hypothesis is based on the protective role of the drugs acting on ACE2. Therefore, this review discusses the impact and challenges of using ACE2 as a target in the current therapy of COVID-19.

KW - Angiotensin converting enzyme 2 (ACE2)

KW - Azithromycin

KW - COVID-19

KW - Hydroxychloroquine

KW - Vitamin D

KW - Zinc

UR - http://www.scopus.com/inward/record.url?scp=85107218784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85107218784&partnerID=8YFLogxK

U2 - 10.26355/eurrev_202105_25963

DO - 10.26355/eurrev_202105_25963

M3 - Article

C2 - 34109607

AN - SCOPUS:85107218784

SN - 1128-3602

VL - 25

SP - 3923

EP - 3932

JO - European review for medical and pharmacological sciences

JF - European review for medical and pharmacological sciences

IS - 10

ER -

Mapping the effect of drugs on ACE2 as a novel target site for COVID-19 therapy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this