Maternal and fetal health outcomes in systemic lupus erythematosus pregnancies in the Emirati population: A comparative study

Hiba I. Khogali, Ghada S.M. Al‐Bluwi, Virgie Guy Pedo, Ali M. Al Dhanhani

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Objectives: To evaluate adverse pregnancy outcomes in patients with systemic lupus erythematosus (SLE), compare their maternal and fetal outcomes with those of age-matched pregnant women without SLE, and identify factors linked to increased risks of adverse outcomes. Methods: Medical records from Tawam Hospital were reviewed retrospectively to identify patients with SLE and a history of pregnancy. Demographics, clinical variables, and maternal and fetal outcomes were obtained. A one-to-one age-matched healthy control group was randomly selected. The outcomes and odd ratios of women with and without SLE were compared, and factors associated with adverse pregnancy outcomes were examined. Results: The outcomes of 78 SLE pregnancies in 39 women were analyzed. Adverse maternal outcomes, such as gestational diabetes mellitus (GDM), occurred in 32% of pregnancies, whereas adverse fetal outcomes, such as low-birth weight and preterm deliveries, occurred in 51% of pregnancies. Pregnant women with SLE had a 5-fold higher risk of GDM, had higher odds of maternal hypertension, and were more likely to deliver through cesarean section than those without SLE. Preterm deliveries and low-birth weight were also more common in SLE pregnancies. Steroid use during pregnancy was significantly associated with an increased risk of GDM development. Lupus nephritis, maternal hypertension, pre-eclampsia, and GDM were linked to preterm deliveries. Conclusion: Pregnant women with SLE were at a higher risk for adverse maternal and fetal outcomes than age-matched pregnant women without SLE. These findings can guide clinical management and emphasize the need for close monitoring of SLE pregnancies.

Original languageEnglish
Pages (from-to)1453-1461
Number of pages9
Issue number12
Publication statusPublished - Oct 2023


  • Systemic lupus erythematosus
  • adverse pregnancy outcomes
  • fetal outcomes
  • maternal outcomes
  • pregnancy
  • preterm

ASJC Scopus subject areas

  • Rheumatology


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