Maternal sickle cell anemia and neonatal isoimmunization

H. Narchi, E. Ekuma-Nkama

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Objective: To study the risk of alloimmunization in pregnant women with sickle cell disease (SCD) and of isoimmunization in their offspring. Method: Thirty mothers with SCD were studied and their 35 neonates (group 1) were compared with 538 infants of mothers without hemoglobinopathies (group 2). Result: Six mothers with SCD developed alloantibodies. There was no correlation with maternal age (P = 0.6), parity (P = 0.18) or blood transfusions (P = 0.4). The risk of alloimmunization by transfusion was 20%. Six neonates were isoimmunized, a higher incidence than in group 2 (P = 0.02; relative risk 3.07). Five had ABO incompatibility and only one had anti-c isoimmunization. All had reticulocytosis, jaundice and required phototherapy, one developed anemia but none required blood transfusion. Conclusion: Although alloimmunization was common in mothers with SCD and isoimmunization in their offspring, it was rarely due to non-ABO alloantibody. There was no significant neonatal morbidity.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalInternational Journal of Gynecology and Obstetrics
Issue number2
Publication statusPublished - Aug 1 1998
Externally publishedYes


  • Alloimmunization
  • Isoimmunization
  • Neonate
  • Pregnancy
  • Sickle cell anemia
  • Transfusion

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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